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Merck Breaks Ground on $3 Billion Center of Excellence for Pharmaceutical Manufacturing in Elkton, Virginia

By News

The expansion underscores Merck’s commitment to invest more than $70 billion in U.S. research, development and capital projects

RAHWAY, NJ, Oct. 20, 2025 – Merck (NYSE: MRK), known as MSD outside of the United States and Canada, announced today the start of construction for a $3 billion, 400,000-square-foot pharmaceutical manufacturing facility at its Elkton, Virginia, site.

Merck’s investment in the Center of Excellence for Pharmaceutical Manufacturing is part of a more than $70 billion investment beginning in 2025 to expand domestic manufacturing and research and development — not including any future business development transactions in R&D — to drive its long-term growth and strengthen the status of the U.S. as a global leader in biopharmaceutical innovation.

“Today is an important milestone for Merck, for Virginia, for manufacturing in the United States and, most importantly, for the patients we serve,” said Robert M. Davis, chairman and chief executive officer, Merck. “This investment helps advance our goal of providing new, innovative treatment options for people facing serious health challenges in the U.S. and around the world.”

The $3 billion expansion celebrated today builds on Merck’s nearly 85-year history in Elkton, Virginia, enhancing the site with a state-of-the-art pharmaceutical Center of Excellence that will include both Active Pharmaceutical Ingredient and Drug Product investment supporting small molecule manufacturing and testing and will potentially create more than 500 full-time roles as well as 8,000 construction jobs.

“Merck’s transformational $3 billion commitment to locate its Center of Excellence marks a giant leap forward for both America’s and Virginia’s life sciences sector,” said Gov. Glenn Youngkin. “It deepens the company’s long-standing commitment to innovation and strengthens the Commonwealth’s position as the emerging national leader in biopharmaceutical advanced manufacturing and life sciences. With hundreds of new jobs and cutting-edge capabilities coming to the Shenandoah Valley, we’re building a future where Virginians lead the way in developing lifesaving medicines for patients around the world.”

A continued commitment to investing in U.S. innovation

For more than 130 years, Merck has been committed to saving and improving lives by developing and delivering life-changing medicines and vaccines to treat diseases in both humans and animals. And as a U.S.-based company, Merck has put capital behind American biotech projects for decades with real results — not just promises.

“Merck’s investment announced today shows exactly what happens when pro-growth policies like H.R. 1 are signed into law,” said NAM President and CEO, Jay Timmons. “By strengthening and making permanent a full suite of competitive tax policies, Congress provided manufacturers with the tax certainty we need to plan, invest, hire and lead. Manufacturers will continue to work with policymakers to advance a comprehensive manufacturing strategy that not only helps manufacturers win — it helps America win.”

This year alone, Merck has announced nearly $6 billion in manufacturing investments across North Carolina, Delaware, Kansas and Virginia that are anticipated to create more than 1,600 new American jobs — punctuated by shovels in the ground and ribbon cuttings:

  • In March, Merck announced the completion of construction on a $1 billion, 225,000-square-foot state-of-the-art facility to expand vaccine production capacity in Durham, North Carolina, expected to generate nearly 400 full-time roles and roughly 4,000 construction jobs.
  • In April, the company broke ground on Merck Wilmington Biotech, a $1 billion, 470,000-square-foot state-of-the-art biologics center of excellence in Wilmington, Delaware, to enable the launch and commercial production of next-generation biologics and therapies.
  • In May, Merck Animal Health announced the $895 million expansion of its manufacturing facility in De Soto, Kansas, anticipated to create 2,500 construction jobs and more than 200 full-time commercial manufacturing roles.

In addition, Merck plans to invest $3 billion in biologics and small molecule manufacturing sites and capabilities in the U.S., which is expected to create more than 800 jobs, while also investing more than $3.5 billion in its Rahway, N.J. headquarters, which is expected to create roughly 1,000 jobs across research and clinical manufacturing. The company’s efforts across the U.S. will further fortify domestic production and distribution of U.S. medicines and vaccines to protect patients and are forecasted to create more than 48,000 construction-related employment opportunities by 2029.

“For almost 85 years, our Elkton site has been a beacon of innovation in our proud legacy of delivering leading-edge science for patients,” said Sanat Chattopadhyay, executive vice president and president, Merck Manufacturing Division. “We’re proud to be part of the Elkton community, where generations have contributed to our important work with determination, accountability, teamwork and grit.”

Please visit the Merck media library for additional materials and information about our ongoing commitment to investing in U.S. manufacturing and innovation.

About Merck

At Merck, known as MSD outside of the United States and Canada, we are unified around our purpose: We use the power of leading-edge science to save and improve lives around the world. For more than 130 years, we have brought hope to humanity through the development of important medicines and vaccines. We aspire to be the premier research-intensive biopharmaceutical company in the world – and today, we are at the forefront of research to deliver innovative health solutions that advance the prevention and treatment of diseases in people and animals. We foster a diverse and inclusive global workforce and operate responsibly every day to enable a safe, sustainable and healthy future for all people and communities. For more information, visit www.merck.com and connect with us on X (formerly Twitter)FacebookInstagramYouTube and LinkedIn.

Forward-Looking statement of Merck & Co., Inc., Rahway, N.J., USA

This news release of Merck & Co., Inc., Rahway, N.J., USA (the “company”) includes “forward-looking statements” within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. These statements are based upon the current beliefs and expectations of the company’s management and are subject to significant risks and uncertainties. If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements.

Risks and uncertainties include but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of pharmaceutical industry regulation and health care legislation in the United States and internationally; global trends toward health care cost containment; technological advances, new products and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approval; the company’s ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of the company’s patents and other protections for innovative products; and the exposure to litigation, including patent litigation, and/or regulatory actions.

The company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise. Additional factors that could cause results to differ materially from those described in the forward-looking statements can be found in the company’s Annual Report on Form 10-K for the year ended December 31, 2024 and the company’s other filings with the Securities and Exchange Commission (SEC) available at the SEC’s Internet site (www.sec.gov).

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Media Contacts:

John Cummins

john.cummins2@merck.com

Ned Ehrbar

ned.ehrbar@merck.com

Investor Contacts:

Peter Dannenbaum

(732) 594-1579

Steven Graziano

(732) 594-1583

Phlow Corp. Selected by the U.S. Food and Drug Administration Commissioner’s First-Ever National Priority Voucher Pilot Program to Advance Manufacturing of a Critical Essential Medicine in America

By News

RICHMOND, Va., October 16, 2025 – Phlow Corp., a leading American advanced pharmaceutical contract development and manufacturing organization (CDMO), today announced that the active pharmaceutical ingredient for ketamine will be included in the first-ever U.S. Food and Drug Administration (FDA) Commissioner’s National Priority Voucher (CNPV) Pilot Program. This designation recognizes Phlow’s leadership in advancing domestic manufacturing of essential and life-changing medicines in the United States.

The FDA’s CNPV Pilot Program is designed to accelerate the development and regulatory review of projects that address a U.S. public health crisis, strengthen the U.S. pharmaceutical supply chain, and reduce dependence on foreign manufacturing. Phlow proposed ketamine, a critical medicine widely used as a general anesthetic in both civilian and military medicine settings, for the CNPV Pilot Program earlier this year.

With no current domestic ketamine API suppliers, Phlow’s project, in partnership with the U.S. Department of Health and Human Services’ Administration for Strategic Preparedness and Response (ASPR), is intended to establish a fully domestic, end-to-end supply chain, from raw materials to finished dosage form, closing a vital gap in national health security. As part of the pilot, Phlow will leverage the voucher to accelerate FDA review timelines, ensuring the timely and resilient availability of this essential medicine through secure U.S.-based production.

“Phlow is pioneering bold solutions that restore pharmaceutical sovereignty to the United States. We are deeply committed to ensuring our Nation stands ready to develop, manufacture, and deliver life-changing medicines with speed, security, and confidence,” said Eric Edwards, M.D., Ph.D., CEO of Phlow. “We are honored to have been selected to participate in the FDA Commissioner’s National Priority Voucher pilot program. This critical initiative will accelerate our efforts to support domestic production of the active pharmaceutical ingredient for ketamine, further strengthening resilience in the U.S. supply chain.”

Our nation has suffered from multi-year ketamine shortages, with a notable shortage lasting from February 2018 to August 2025. By advancing U.S.-based API production, Phlow is helping to ensure a more secure, transparent, and reliable supply of this critical medicine while reducing the nation’s dependence on overseas sources.

Phlow’s capabilities span process research and development, kilo-scale and metric ton-scale API production, and strategic pharmaceutical ingredient reserves. Through this infrastructure, Phlow is reshaping how life-changing medicines are developed and manufactured in the U.S., ensuring high-quality, affordable, and sustainable access to patients and health systems.

“This is a significant initiative that validates the advanced manufacturing path that Phlow has been building from day one. It reinforces our belief that pharmaceutical sovereignty is critical to national preparedness and should send a strong signal to the market that there are real, tangible benefits to making medicines in America end-to-end,” Edwards concluded.

About Phlow Corp.

Phlow, a B Corporation™, helps brilliant minds bring medicines to life through advanced development and manufacturing in America. Focused on innovations in drug substance development, Phlow supports government and private industry customers to create innovative approaches with scientific expertise, world-class manufacturing, and tech-enabled processes that propel the industry forward to a new standard as we create the future of how medicines are made. As a modern contract development and manufacturing provider, we measure our impact by increasing speed to market, reducing waste, and offering an environmentally friendly approach to manufacturing medicines that lead to healthy, resilient communities. For more, visit phlow-usa.com.

AstraZeneca plans to increase investment and scope of its Virginia manufacturing facility to $4.5 billion, creating 3,600 new jobs

By News

New manufacturing facility to be located near Charlottesville, in Albemarle County, Virginia will develop and manufacture a broader range of medicines including weight management, metabolic and cancer technologies

Facility marks cornerstone of $50 billion investment in medicines R&D and manufacturing in America

AstraZeneca today announces that it will invest $4.5 billion in its new manufacturing facility in Virginia, a proposed increase of $500m to support the enhanced manufacturing capability of a broader range of medicines including cancer treatments. This is part of the historic $50 billion investment announced in July 2025. The new facility will be located at Rivanna Futures in Albemarle County and is expected to create approximately 3,600 direct and indirect jobs, powering economic growth and Virgina’s leadership at the forefront of life sciences innovation.

The manufacturing facility is expected to create 600 highly skilled jobs in Virginia including engineers, scientists, process facilitators which includes an additional 100 jobs as a result of the expansion. A further 3,000 jobs will be created to support the construction of the facility including engineers, skilled trades and construction workers. It will be at the forefront of technological innovation, leveraging AI, automation, and data analytics to optimise production.

The new facility will produce drug substance for AstraZeneca’s weight management and metabolic portfolio, including oral GLP-1, baxdrostat, oral PCSK9 and combination small molecule products.  Today, the Company is announcing it has expanded the scope to also include state-of-the-art manufacturing for our leading antibody drug conjugate (ADC) cancer portfolio. Work will start immediately with the facility expected to be operational in the next four to five years.  This investment will bring critical medicine manufacturing capabilities to the United States and offers assurance from a national security and health sovereignty perspective.

Dr. Mehmet Oz, Centers for Medicare & Medicaid Services Administrator, said: “We cannot truly be a wealthy nation without being a healthy nation. Today’s groundbreaking demonstrates the Trump Administration’s commitment to onshoring drug manufacturing and strengthening supply chains to improve Americans’ access to medication. I congratulate AstraZeneca for their investment and invite other foreign manufacturers to follow suit.”

Governor Glenn Youngkin, Commonwealth of Virginia, said: “AstraZeneca’s $4.5 billion investment is the largest in the company’s history and a game-changer for American drug manufacturing. The investment is set to create 3,600 jobs in Virginia, strengthening America’s ability to produce life-saving medicines. Thanks to programs like the Virginia Business Ready Sites Program and the Virginia Talent Accelerator Program, AstraZeneca is going to be able to hit the ground running. That means better jobs, better medicine, and better opportunities for the people of Virginia.”

Pascal Soriot, Chief Executive Officer, AstraZeneca, said: “With our $4.5 billion investment in Virginia, the largest in AstraZeneca’s history, we are not only building a state-of-the-art manufacturing facility, but also driving life sciences innovation and economic growth. This new facility will create thousands of jobs and strengthen America’s national security and health sovereignty. I also want to thank Governor Youngkin and his team for their energy and vision. We have found in Virginia an amazing team that moves at incredible speed to build a better future for this Commonwealth and the American people.”

The Virginia Economic Development Partnership worked with Albemarle County and the General Assembly’s Major Employment and Investment Project Approval Commission to secure the project for Virginia.

Notes

AstraZeneca
AstraZeneca (LSE/STO/Nasdaq: AZN) is a global, science-led biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines in Oncology, Rare Diseases, and BioPharmaceuticals, including Cardiovascular, Renal & Metabolism, and Respiratory & Immunology. Based in Cambridge, UK, AstraZeneca’s innovative medicines are sold in more than 125 countries and used by millions of patients worldwide. Please visit astrazeneca.com and follow the Company on Social Media @AstraZeneca.

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