News Archive

The angel investor market in 2014 had a slight correction in investment dollars and in the deal size. Total investments in 2014 were $24.1 billion, a decrease of 2.8% over 2013, according to the Center for Venture Research at the University of New Hampshire. A total of 73,400 entrepreneurial ventures received angel funding in 2014, an increase of 3.8% over 2013 investments. The number of active investors in 2014 was 316,600 individuals, an increase of 5.9% from 2013. The change in both total dollars and the number of investments resulted in a deal size for 2014 that was smaller than in 2013 (a decrease in deal size of 6.4% from 2013). These data indicate that angels were active investors in 2014 but at decreased valuations than in previous years, indicating a slight market correction in valuations. However, the $24.1 billion is a robust amount and is close to the market high of $26.0 billion that occurred in 2007.

Washington, D.C., mayor Muriel Bowser has named Matt Bailey the first director of technology innovation for the Office of the Chief Technology Officer.

The appointment is part of an effort to create innovative solutions to address the challenges that Washington, D.C., faces as a city, said Bowser in a release.

There seems to be something special about coworking spaces. As researchers who have, for years, studied how employees thrive, we were surprised to discover that people who belong to them report levels of thriving that approach an average of 6 on a 7-point scale. This is at least a point higher than the average for employees who do their jobs in regular offices, and something so unheard of that we had to look at the data again.

Forest City Enterprises and its partners on Friday will break ground on a $65.6 million, 165,000-square-foot building at 1812 Ashland Ave. that will be a hub for Johns Hopkins University’s efforts to commercialize research.

Construction is expected to be completed in August 2016.

When it came to deciding where drug giant AstraZeneca would expand its work making biologic medicines, there was no question the project would happen in Maryland, the company’s top U.S. official said this Wednesday. “I don’t know where else we would go in terms of innovation,” said Paul Hudson, AstraZeneca’s U.S. president as the company unveiled progress on its $200 million expansion in Frederick.

A mid-stage trial of Roche Holding AG’s experimental immunotherapy showed that it doubled the likelihood of survival for lung cancer patients with the highest levels of a specific biomarker.

The drug, known by the code name MPDL3280A, is part of a new class designed to help the body’s immune system fend off cancer by blocking a protein known as Programmed Death receptor (PD-1), or a related target known as PD-L1, used by tumors to evade the body’s defenses.

Cancer is costly, pervasive and a growing problem for businesses.

It already accounts for between 10 percent and 15 percent of employers’ health costs. As employees work longer before retiring, the bill could get bigger. That’s why Johns Hopkins Medicine is launching a new program that could reduce the business costs of cancer by helping employees better prepare for and cope with it.

Luis Branco didn’t originally plan to head to the front lines of the Ebola crisis.

His Germantown-based startup, Zalgen Labs LLC, was testing its diagnostic kits in Sierra Leone last May for a different illness called Lassa Fever, which is endemic in West Africa and kills scores of people there every year. But then, Ebola began to spread.

AstraZeneca (NYSE: AZN) announced that it has entered an agreement with Abbott (NYSE: ABT), a global healthcare company, to develop companion diagnostic tests to identify patients with severe asthma who are most likely to benefit from the investigational biological therapy, tralokinumab. To date, no companion diagnostic blood tests have been approved for use in asthma.

Under the terms of the agreement, Abbott will develop and commercialise diagnostic tests to measure serum levels of the proteins periostin and DPP4 (dipeptidyl peptidase-4), which have been identified as potential predictive biomarkers of up-regulated IL-13 in severe asthma. The tests will be developed in conjunction with AstraZeneca’s Phase III trial of tralokinumab, a potential treatment for patients with severe, inadequately controlled asthma, developed by the company’s biologics research and development arm, MedImmune. Periostin has been previously described as a potential biomarker for asthma1, and DPP4 is a novel and promising predictive biomarker identified by MedImmune.