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GSK files world’s first malaria vaccine

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GSK has submitted an application for the world’s first malaria vaccine to the European Medicines Agency (EMA).

The vaccine candidate, RTS,S, is produced in yeast cells and targets the Plasmodium falciparum malaria parasite, most common in sub-Saharan Africa. It uses GSK’s proprietary AS01 adjuvant system, containing QS-21 Stimulon adjuvant licensed from Antigenics, a subsidiary of Agenus, as well as monophosphoryl lipid A (MPL) and liposomes.

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Can Mobile Technologies and Big Data Improve Health? – MIT Technology Review

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After decades as a technological laggard, medicine has entered its data age. Mobile technologies, sensors, genome sequencing, and advances in analytic software now make it possible to capture vast amounts of information about our individual makeup and the environment around us. The sum of this information could transform medicine, turning a field aimed at treating the average patient into one that’s customized to each person while shifting more control and responsibility from doctors to patients.

The question is: can big data make health care better?

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Strand Genomics Inc: Genomic Insights for Personalized Medical Diagnostics and Therapies – CIO Review

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The implications of the world’s largest collaborative biological project in the year 2000—the Human Genome Project-combined with the Big Data revolution in the medical sciences holds out tremendous promise for human health. Recognizing the imminent need for the next generation of bioinformatics and genomics tools, four academic entrepreneurs from the prestigious Indian Institute of Science co-founded Strand Genomics Inc. (Strand). “Our focus is on personalized clinical genomics and molecular diagnostics. To address the grand challenge of the “$1000 genome and million dollar interpretation”, we have developed a clinical genomics interpretation and reporting platform, StrandOmics,” says Vijay Chandru, Ph.D, Co-founder, Chairman and CEO, Strand.

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NextNav raises $70M Series D from NEA, others – Washington Business Journal

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NextNav LLC, the bicoastal location services venture launched by XM Satellite Radio founder Gary Parsons, announced on Thursday a $70 million Series D funding led by New Enterprise Associates and Oak Investment Partners.

The eight-figure round is the latest high-dollar financing for NextNav, which two years ago reported a $50 million raise from Columbia Capital. Columbia also joined in the most recent round, alongside Telcom Ventures and Goldman Sachs Investment Partners.

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NHLBI Funding and Research Opportunities and Announcements for July 23, 2014

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Funding and Research Opportunities

The following funding opportunity announcements from the NHLBI or other components of the National Institutes of Health, might be of interest:

NIH Guide Notice: 

  • Request for Information: Shared Instrumentation Grant Program (S10) 
    (NOT-OD-14-104) Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs
  • Extramural Loan Repayment Program for Clinical Researchers (LRP-CR)
    (NOT-OD-14-105) National Institutes of Health
  • Extramural Clinical Research Loan Repayment Program for Clinical Researchers from Disadvantaged Backgrounds (LRP-IDB)
    (NOT-OD-14-106) National Institutes of Health
  • Extramural Loan Repayment Program for Pediatric Research (LRP-PR)
    (NOT-OD-14-107) National Institutes of Health
  • Extramural Loan Repayment Program for Contraception and Infertility Research (LRP-CIR)
    (NOT-OD-14-108) National Institutes of Health
  • Extramural Loan Repayment Program for Health Disparities Research (LRP-HDR)
    (NOT-OD-14-109) National Institutes of Health
  • Notice of the National Institute on Deafness and Other Communication Disorders (NIDCD) Participation in PA-14-114 “Behavioral Interventions to Address Multiple Chronic Health Conditions in Primary Care (R01)”
    (NOT-DC-14-003) National Institute on Deafness and Other Communication Disorders
  • Notice of Change to the Award Budget and Submission Requirements for PAR-12-198 “Improving Diet and Physical Activity Assessment (R01)”
    (NOT-DK-14-023) National Institute of Diabetes and Digestive and Kidney Diseases
  • Notice of NICHDs Participation in PAR-13-055 “Dissemination and Implementation Research in Health (R01)” 
    (NOT-HD-14-017) Eunice Kennedy Shriver National Institute of Child Health and Human Development
  • Request for Information: NHLBI Whole Genome Sequencing Project (NHLBI-WGS)
    (NOT-HL-14-030) National Heart, Lung, and Blood Institute
  • Notice of the Change in the Expiration Date for PA-11-347 “NINDS SBIR Technology Transfer (SBIR-TT [R43/R44])”
    (NOT-NS-14-038) National Institute of Neurological Disorders and Stroke

Please note that most links to RFAs, PAs, and Guide Notices will take you to the NIH Web site. RFPs will take you to FedBizOpps. Links to RFPs will not work past their proposal receipt date. Archived versions of RFPs posted on FedBizOpps can be found on the FedBizOpps site using the FedBizOpps search function. Under “Document to Search,” select Archived Documents.

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Cybersecurity firms among top recipients of venture funding in Maryland – baltimoresun.com

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Maryland companies raised $64 million in venture capital funding this spring, with some of the biggest payouts flowing to Baltimore cybersecurity startups.

That’s according to the latest MoneyTree report from PricewaterhouseCoopers and the National Venture Capital Association. The report, which uses Thomson Reuters data, tracks money flowing to startups and later-stage firms across the country.

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Aris Melissaratos leaves Johns Hopkins to become an interim dean at Stevenson University – Baltimore Business Journal

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Former state economic development secretary Aris Melissaratos is leaving Johns Hopkins University for a job where he’ll have more power.

Melissaratos, who had been with Hopkins for seven years, on July 17 joined Stevenson University as interim dean of the Brown School of Business and Leadership. Melissaratos said he has always had an interest in academia and now will be able to play a leading role in preparing students to join the local workforce.

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Cerecor raises $16M for PhII study of ‘Special K’ depression remedy – FierceBiotech

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Baltimore-based Cerecor has gathered up the first half of a $33 million B round, with plans to devote much of that money to a midstage development program for an experimental depression therapy recently punted by a restructuring Merck ($MRK).

In documents filed with the SEC, the biotech noted that it has raised $16.2 million of a planned $33.2 million round. New Enterprise Associates, Apple Tree Partners and MPM Capital led the round, which is also going to fund R&D efforts on its catechol-O-methyltransferase inhibitor platform for conditions “characterized by impairment of executive function and working memory.”

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