The University of Louisville announced today that a grant from the National Institutes of Health will combine with matching funds from the university to create a new $6.1 million initiative to commercialize discoveries made by UofL researchers.

UofL is one of just three institutions in the United States selected as a Research Evaluation and Commercialization Hub (REACH) by the NIH. The REACH award consists of $3 million over three years matched by an additional $3.1 million from UofL.

Pharmaceutical company Teva has offered to buy fellow drug maker Mylan in a deal that could be worth $40 billion.

In the proposal, confirmed yesterday (April 21), Teva offered Mylan $82 per share.

Last week, Mylan’s executive chairman Robert Coury dismissed rumours of a merger with Israel-based Teva.

The Food and Drug Administration is making as much as $1 million in grant funding available for mining a large database of electronic health records to conduct postmarket surveillance of drug safety.

The FDA’s Center for Drug Evaluation and Research (CDER) will award a one-year grant by summer to a single bidder to develop “new analytic methodologies” to look for signs of pharmaceutical-related safety problems in the Mini-Sentinel Distributed Database, an FDA-funded pilot with access to 178 million medical records.

CORE PROGRAM APPLICATION  DEADLINE 5 PM, FRIDAY, MAY 1ST  

The Core Program is Leadership Montgomery’s (LM) hallmark program. It is a highly interactive and life-enriching nine-month course that makes a significant contribution to Montgomery County’s well-being by providing intensive hands-on study and in-depth discussion of current issues facing the County, including, transportation, education, public safety, business, planning, economic development, communities diversity and the arts. Click here to read about a session. Click here to see the session agendas.

A hallmark of Parkinson's disease is the progressive loss of nigrostriatal dopaminergic neurons. We derived human neuroepithelial cells from induced pluripotent stem cells and successfully differentiated them into dopaminergic neurons within phase-guided, three-dimensional microfluidic cell culture bioreactors. After 30 days of differentiation within the microfluidic bioreactors, in situ morphological, immunocytochemical and calcium imaging confirmed the presence of dopaminergic neurons that were spontaneously electrophysiologically active, a characteristic feature of nigrostriatal dopaminergic neurons in vivo. Differentiation was as efficient as in macroscopic culture, with up to 19% of differentiated neurons immunoreactive for tyrosine hydroxylase, the penultimate enzyme in the synthesis of dopamine. This new microfluidic cell culture model integrates the latest innovations in developmental biology and microfluidic cell culture to generate a biologically realistic and economically efficient route to personalised drug discovery for Parkinson's disease.

What if the answer to reducing health costs of the most expensive patients stems from listening to the hunches of home care workers with little — if any — medical training?

That’s the premise tech startup Care at Hand Inc. used to predict and prevent an estimated $6.5 million in Medicare spending by reducing hospitalizations among aging patients in Massachusetts.

The City of New York Early-Stage Life Sciences Funding Initiative represents an unprecedented public-private partnership across world-class academic institutions, industry leaders, top-tier investors, and the philanthropic community.

Established by the New York City Economic Development Corporation (NYCEDC) with at least $50 million in matching funds from top-tier venture capital partners including Celgene Corporation, GE Ventures, and Eli Lilly & Company, the funding partnership will deploy a minimum of $150 million and seeks to launch 15 to 20 breakthrough ventures by 2020.

The Qiagen campus in Germantown is large, open and modern looking.

Its 25-acre site on Germantown Road houses a mostly glass office building connected to a newer addition that provides space for manufacturing and packaging the company’s biotech products.

NO one who lived through the 1990s would have suspected that one day people would look back on the period as a golden age of bipartisan cooperation. But in some important ways, it was. Amid the policy fights that followed the Republican victories of 1994, President Bill Clinton and the new majorities in Congress reached one particularly good deal: doubling the budget for the National Institutes of Health.

The decision was bipartisan, because health is both a moral and financial issue. Government spends more on health care than any other area. Taxpayers spend more than $1 trillion a year for Medicare and Medicaid alone, and even more when you add in programs like Veterans Affairs, the Children’s Health Insurance Program and the Indian Health Service.

The life sciences community presented a vision this week in which the Washington, DC region becomes a top 3 biotech hub by 2023. What role will economic development incentives play in achieving this status?

Industry, academic, nonprofit, investment and government partners participated in the Regional Biotech Forum: Growing Our Ecosystem, a program spearheaded by BioHealth Innovation, AstraZeneca, MedImmune and the Tech Council of Maryland and supported by BioMaryland, Virginia Bio, Montgomery County, MD among others.

From Christy Wyskiel,Senior Advisor to the President, Johns Hopkins University

Dear Colleagues,

We are pleased to announce that Neil Veloso will join Johns Hopkins Technology Ventures as the executive director of technology transfer, effective May 18, 2015.

Neil has extensive experience in technology transfer and commercialization. He has spent the last nine years of his career in a variety of roles at Cleveland Clinic Innovations (CCI) in Ohio. Currently, he is serving as the senior director of innovation management, a role in which he directs technology commercialization at Cleveland Clinic and at seven of CCI's Innovation Alliance Partners. In this role, Neil focuses on commercialization strategy across a broad portfolio of both academic and hospital system assets. He manages a team that advises inventors, administers intellectual property, and promotes commercialization through licensing, new venture creation and the development of industry partnerships. Neil's collaborative leadership style and ability to work with myriad constituents has been cited repeatedly as one of his great strengths by former colleagues and industry partners.   

A few months into 2015, D.C.’s tech industry is continuing to prove itself a major region for venture capital investing interest. Based on an NVCA/PwC report provided to DC Inno, the District is ranked No. 9 among major U.S. regions for investments during Q1. In a quarter that saw vibrant deal flow and exceptional venture raises, the D.C. focused software sector did especially well by raising $220 million in investment dollars.

MaxCyte® Inc., the pioneer in cell therapies using scalable, high-performance cell transfection systems, today announces a strategic research collaboration with Johns Hopkins University (JHU) to develop unique Chimeric Antigen Receptor (CAR) T-cell therapies, which harness patients’ own immune systems to combat cancers.

MaxCyte’s unique approach to CAR cell therapy allows targeting of solid tumor cancers by enabling control over the on-target, off-tumor toxicity, which limits other CAR therapies to hematological cancers. MaxCyte achieves this by introducing the CAR construct as a transiently expressing messenger RNA (mRNA), thus allowing control of the duration of expression and toxicity against target antigens in normal tissue. This unique approach also avoids the cell expansion step required for standard approaches, dramatically reducing manufacturing time and expense for CAR therapies from days or weeks to a matter of hours.

The end may be near for Montgomery County’s Department of Economic Development.

County Executive Ike Leggett, speaking in North Bethesda as a panelist during the Washington Business Journal’s inaugural On the Road event, announced Tuesday he intends to replace Montgomery County's economic development agency with a public-private authority, along the lines of Fairfax County’s Economic Development Authority.

The list of the top five health systems in the Baltimore area was static this year, with Johns Hopkins at No. 1 and Mercy Health Services at No. 5.

The data comes from our List of Health Systems in the Baltimore area, which is available to subscribers.

Funding and Research Opportunities

The following funding opportunity announcements from the NHLBI or other components of the National Institutes of Health, might be of interest:

Notices:

Reminder: NIH Policy on Application Compliance
(NOT-OD-15-095) National Institutes of Health

Notice of Availability of Frequently Asked Questions for RFA-HL-16-002 "Sudden Cardiac Death in the Young: Population Based Studies (U01)" and the Sudden Death in the Young Case Registry 
(NOT-HL-15-258)
National Heart, Lung, and Blood Institute

Requests for Applications:

Undiagnosed Diseases Gene Function Research (R21)
(RFA-RM-15-004)
NIH Roadmap Initiatives
National Institute of General Medical Sciences
The Common Fund/Office of Strategic Coordination
Application Receipt Date(s): June 24, 2015

Please note that most links to RFAs, PAs, and Guide Notices will take you to the NIH Web site. RFPs will take you to FedBizOpps. Links to RFPs will not work past their proposal receipt date. Archived versions of RFPs posted on FedBizOpps can be found on the FedBizOpps site using the FedBizOpps search function. Under “Document to Search,” select Archived Documents.

Tokai Pharmaceuticals, Inc. (NASDAQ:TKAI), a clinical-stage biopharmaceutical company focused on developing novel therapies for prostate cancer and other hormonally-driven diseases, today announced that scientists in the laboratory of Vincent Njar, PhD, at the University of Maryland School of Medicine presented preclinical data showing that galeterone and novel analogs of galeterone inhibited growth, survival and migration of human pancreatic ductal adenocarcinoma (PDAC) cells.

These data were presented in a poster presentation titled, “Galeterone and Its Novel Analogs Induce Profound Anti-Cancer Activities in Human Pancreatic Cancer Cell Lines,” abstract number 1764, at the 2015 American Association for Cancer Research (AACR) in Philadelphia, Pennsylvania.

Thanks to our back to back April/May sponsor, The University of Maryland's Biotech Research and Education Program (BREP), who is sponsoring the upcomig event in Rockville on May 20th at the @AmericanTapRoom. BioBuzzMoCo events always draw an awesome crowd so join BREP for an awesome evening in the heart of the region's growing BioHub.

MAY 12, 2015, 2-3 pm ET

The landscape of potential customers for biomedical products can be complicated, with patients, providers and payers assigning different values to new technologies. Companies must navigate this landscape to find the individuals who will actually make the decision to purchase their products. In this webinar, entrepreneur and educator Rana Gupta will talk about how customers can not only help biomedical innovators to define the value proposition for their products, but can also guide and fund their product development work.

The Institute for Genome Sciences (IGS), created in 2007, is an inter-disciplinary, multi-departmental team of collaborative investigators within the University of Maryland School of Medicine led by Claire M. Fraser, Ph.D., one of the world’s preeminent genome scientists.

IGS uses large-scale, cutting-edge experimental and computational tools to better understand gene and genome function in health and disease, to study molecular and cellular networks in a variety of model systems, and to generate data and resources of value to the international scientific community.

Blood draws typically require trained professionals to perform and can be both frightening and painful to patients. Tasso, Inc., a spinoff of the Unviersity of Wisconsin-Madison, has developed a device that can be applied by the patients themselves to nearly painlessly draw blood.

The device works thanks to capillary action, slowly pulling in blood through a tiny channel over a two minute period. Once the process is complete, the patient simply takes the device to a clinical lab for testing. Since current methods require refrigeration of blood samples during shipment, DARPA is giving Tasso $3 million to work with other firms to develop a way to extend to a week the time the blood samples can be safely stored at up to 140° F (60° C).

The tech incubator 1776 is a collegial place, with offices painted in lively colors, couches to greet visitors, and members who share seats, desks and the fixings for peanut butter and jelly sandwiches.

It’s an atmosphere carefully cultivated by its founders, Evan Burfield and Donna Harris, and it helped position the outfit as a caretaker, connector and capital provider for tomorrow’s big technology companies.

In the face of growing criticism and impatience with the Meaningful Use EHR incentive program, National Health IT Coordinator Dr. Karen DeSalvo remains upbeat but aware of the tough work ahead to achieve the vision of a learning health system underpinned by a network of interoperable EHRs.

“Interoperability is a priority, but it is still just a means to an end,” De Salvo said Thursday morning in a keynote session on the last day of HIMSS15 at McCormick Place in Chicago. Without interoperability, it will be difficult to achieve healthcare payment and delivery reform, she added.

Washington companies raised more venture capital funding in the first quarter than they have during the first three months of any year in more than a decade, building on momentum the industry mustered up late last year.

During the first quarter, 38 Washington companies hauled in roughly $329.9 million from venture capitalists, a 55 percent increase over the $212.5 million raised by firms in the region during the same period last year, according to the latest round of data from PricewaterhouseCoopers and the National Venture Capital Association. While that’s down slightly from a surge last quarter, in which investors poured $363.5 million into local companies, it’s well above last year’s sluggish quarterly average ($270.4 million) and the largest first-quarter haul since 2001.

Northrop Grumman Corporation (NYSE:NOC) and the bwtech@UMBC Cyber Incubator announced today that continuous monitoring solutions provider DB Networks® will be the fifth cyber startup to graduate from the highly successful Cync Program. A ceremony marking the occasion is scheduled for next week during the RSA Conference 2015 in San Francisco, California.

OptioLabs of Baltimore joins Cync this month as the newest cyber startup accepted into the program since it began in 2011.

The news broke just after midnight Thursday that D.C. tech accelerator 1776 would acquire Disruption Corp. — both its Crystal Tech Fund, which currently includes 12 portfolio companies, and the startup-focused, data-crunching software that formed the foundation of Paul Singh's Crystal City enterprise.

It can't be denied that 1776 has built a rather explosive brand since it first popped on the scene in 2013. President Barack Obama and United Kingdom Prime Minister David Cameron have toured the premises. Partnerships have been forged with several monster corporations (like Comcast and Microsoft) and, as of this week, two local municipalities (Montgomery and Arlington). Legions of startups work out of the District offices. And Virginia Gov. Terry McAuliffe will be speaking at Thursday's formal announcement of the deal.

The field of blood study and blood-related product development is a small one, and the field of autotransfusion (blood recycling) is even smaller. It often seems like everyone knows everyone else. We've had a lot of great mentors in the blood space from afar, but it hasn't been until we tapped into the inner workings of the Baltimore/DC area that we realized quite how small.

Just six weeks ago, we moved to the Charm City for the DreamIt Health Accelerator program from our medical device manufacturing home in Grand Rapids, Michigan. We were looking for other resources and mentors in both the blood transfusion and global health community to take our company to the next level, and we've found them.

AstraZeneca today announced that MedImmune, its global biologics research and development arm, has entered into a collaboration to conduct clinical trials in immuno-oncology with Immunocore Limited, a privately-held UK-based biotechnology company.

Under the terms of the agreement, Immunocore will conduct a Phase Ib/II clinical trial combining MedImmune’s investigational checkpoint inhibitors MEDI4736 (anti-PD-L1) and/or tremelimumab (anti-CTLA-4) with IMCgp100, Immunocore’s lead T-cell receptor-based investigational therapeutic, for the potential treatment of patients with metastatic melanoma.  MedImmune has an exclusive relationship with Immunocore for the development of IMCgp100 in combination with MEDI4736 and/or tremelimumab, and will have first right of negotiation for the future commercial development of these combinations for tumours expressing glycoprotein 100 (gp100), a tumour-associated antigen.

Baltimore may not have the startup mecca reputation of Silicon Valley or Boston, but it is one of the fastest growing tech talent markets.

The city’s tech talent pool grew by 42 percent between 2010 and 2013, making Baltimore one of the fastest growing tech talent markets in the country, according to a new report by CBRE, a commercial real estate brokerage. Only San Francisco and the San Francisco Peninsula reported a faster growth rate than Baltimore. Tech talent grew 44 percent in those areas.

Venture firm New Enterprise Associates made some massive waves today on news that it’s closed its fifteenth – and largest – fund, which holds $3.1 billion. And a huge swath of that – 30 to 40 percent, according to Fierce - could likely be allocated to the healthcare space.

MedCity News reported initially on NEA’s plans to raise funds – it filed a document with the SEC in January indicating a $2.5 billion fundraise:

Alexandria Real Estate Equities Inc. is opening a Gaithersburg wet lab space in a project that may help fill a gap left when Montgomery County's biotech incubator shuttered last year.

Called Alexandria LaunchLabs, the new space will create five lab and office spaces to accelerate early-stage life science companies. Each will have about 1,200 square feet and have access to supporting infrastructure and amenities such as an on-site gym. BioHealth Innovation, a public-private partnership created in 2011 to foster health and life sciences commercialization in Maryland, will provide startup and entrepreneur-in-residence programs to guide the early-stage life science companies.

Roche aims to have an immunotherapy cancer drug in 11 late-stage trials by the end of the year, the Swiss drugmaker's head of medical affairs for oncology, Nico Andre, said at a conference on Monday.

The Basel-based company's MPDL3280A, which is being tested in melanoma, as well as lung, bladder, kidney, bowel and blood cancers but has not yet been approved to treat any type of cancer, is the furthest developed of this class of drug. Some analysts have said such drugs could generate more than $30 billion in annual sales for the industry as a whole by 2025.

Alexandria Real Estate Equities Inc. made its first modest investment in Kendall Square about 14 years ago, developing a blocky five-story building it named The Science Hotel.

The building, on Memorial Drive, was designed to be an incubator for biotechnology startups as the industry was just emerging in East Cambridge. In the following years, biotech grew explosively in the Kendall Square area, and Alexandria grew, too.

New Enterprise Associates has closed more than $3.1 billion in new capital for its 15th fund and a joint "opportunity fund," the Chevy Chase venture capital giant said Wednesday.

The raise marks the fourth consecutive $2.5 billion-plus fund and brings the total capital under the firm's umbrella since its 1977 inception to nearly $17 billion.

National Coordinator for Health Information Technology Karen B. DeSalvo, M.D., M.P.H., M.Sc., announced today the availability of $1 million in grant funds to support community projects for the Community Interoperability Health Information Exchange (HIE) Program. The funding will help support and enable the flow of health information at the community level, leading to better care and better health.

The Community Interoperability and HIE program will provide funds to up to ten community organizations, state or local government agencies, or other community groups. The awards will help unlock health information and better integrate community resources advancing better care and healthier communities.