Biohealth Innovation
AstraZeneca's global biologics R&D arm MedImmune has entered into a five-year multi-project research collaboration with the University of Sheffield to carry out breakthrough research in cell factory technology process.
With the in cell factory technology, living cells can be controlled and manipulated to make specific proteins with therapeutic benefits.
Johns Hopkins University tops the list of private, non-government employers in the Baltimore region, although three of the top five Baltimore-area employers are health systems — an unsurprising fact given that most workers in the Baltimore area are in health care or education.
Health care and education employees make up 19 percent of workers in the Baltimore area, more than any other supersector, according to May data from the U.S. Bureau of Labor Statistics. Still, there are large employers of many different industry types in the Baltimore area. Subscribers can check out the full list here.
MedImmune, the global biologics research and development arm of AstraZeneca, and the University of Sheffield announced today that they have entered into a multi-project research collaboration to generate breakthrough research in cell factory technology, the process by which living cells can be controlled and manipulated to make specific proteins with therapeutic benefits.
As part of the five-year collaboration, MedImmune will provide funding and in-kind contributions to support University of Sheffield post-doctoral and doctoral research projects to address key challenges in cell engineering. The aim is to produce tools to ensure that manufacturing success is “designed in” from a much earlier stage than occurs with current screening-based strategies, to improve the development and production of biologic medicines. The collaboration will focus on harnessing expertise from both MedImmune and the world-leading group in the University’s Advanced Biomanufacturing Centre to advance research specifically in mammalian cell factories.
Bioscience companies up to 7 years old can now apply for state funding that was formerly available only to younger companies.
BioInnovation Connecticut, managed by Connecticut Innovations, a state financing entity, invests in bioscience companies to speed the path to commercialization through its CT Bioscience Innovation Fund. Until July 1, only companies 3 years old and younger were eligible to apply, said Margaret Cartiera, vice president and fund manager for BioInnovation CT.
It is no secret that 2015 has been a highly active year for deal-making in the life science space. However, what is often overlooked is exactly where in the space those deals are taking place. Life Science Nation’s financing rounds database contains detailed information on over 250 of these rounds that have taken place since January 1 of 2015. We track this data from a variety of sources however as many companies and investors chose not to disclose this information this should be viewed as a sample of the entire data set of financings. With this article will highlight what our data tells us about the rounds that have taken place thus far in 2015 for therapeutics companies around the globe.
Venture-backed biotechs continue their blistering pace of funding. According to the latest MoneyTree Report from PricewaterhouseCoopers (PwC) and the National Venture Capital Association (NVCA), with data from Thomson Reuters, over $2.1B was invested in biotech companies in 2Q 2015, bringing the year to date total to almost $4B(covered here, here). Four of the last five quarters are amongst the largest record-setting quarters in ten years.
It’s one of the best periods for biotech funding in the history of the industry, offering an opportunity for emerging companies to scale and develop their pipelines more significantly than ever before.
Thursday, July 30, 2015 from 6:30 PM to 8:30 PM (EDT) Washington, DC
The Washington DC region is part of an east coast corridor rich in life science talent, technical know-how and business development expertise. Montgomery County, Maryland itself is host to a unique ecosystem of potential resources for startups in health tech: centers of research, strong universities, leading biotech and pharma companies, and government agencies. This ecosystem means that health tech founders can immediately access resources and build the strategic partnerships to support their rapid growth.
This event will discuss Relevant Health, a new health tech startup accelerator program based in Rockville, Maryland, and the regional environment for startups in health tech. Come ready both to hear about opportunities for startups and discuss your experiences and needs as someone interested in building our health tech capital.
Vaxin Inc. today announced that it has added key patents to its expanding Intellectual Property (IP) portfolio. The clinical stage vaccine and immunotherapeutics company confirmed that the United States Patent and Trademark Office (USPTO) has issued a Notice of Allowance for two patents that protect important elements of its Densigen platform technology for immunotherapeutic treatment of Hepatitis B virus infection, and its RespirVec non-invasive adenoviral vector influenza vaccine. The patents include U.S. Application Serial No. 13/977,265 (the ‘265 application) entitled “Fluorocarbon-Linked Peptide Formulation”, and U.S. Application Serial No. 13/426,037 (the ‘037 application) entitled “Rapid and Prolonged Immunologic-Therapeutic”.
A Notice of Allowance is issued after the USPTO makes a determination that a patent can be granted from an application. Vaxin now has 37 patents protecting its products in 13 countries.
The University of Maryland students who join the Startup Shell incubator are all working hard to turn their ideas into successful businesses. As the new executive director of Startup Shell, 20-year-old Chris Szeluga is working just as hard to help make that possible. Now in his third year at UMd, the finance major has been involved in helping grow Startup Shell since it began, during his freshman year. His new role puts a new responsibilities on him though, making Startup Shell rather more than just a club or hobby.
"I consider Startup Shell to be pretty much my full-time job," Szeluga said. "I definitely spend at least 30 to 40 hours a week working on it in some way."
Since Medicaid's creation in 1965, it's become the largest health insurer in the country, covering more than 70 million Americans. Initially covering only poor, single parents and their children, the program now also offers government-subsidized insurance to disabled people, able-bodied adults without kids and some elderly.
The program's expansion may slow down a bit, but it’s not likely to stop anytime soon, and there’s a whole lot of reform going on, along with major shifts in coverage.
It was Coney Island in the early 1900’s. Beyond the Four-Legged Woman, the sword swallowers, and “Lionel the Lion-Faced Man,” was an entirely different exhibit: rows of tiny, premature human babies living in glass incubators.
Barkers, including a young Cary Grant, called out to passersby, enticing visitors to come see the preemies.
The White House is getting ready to honor five years since the creation of Challenge.gov — the central web portal for government competitions intended to spur innovation and solve problems — with a forward-looking celebration.
Touting the $72 million in prizes awarded across 400 challenges in the last five years, the Office of Science and Technology Policy announced a special event this fall that will highlight some of the major breakthroughs and civic issues solved through the program.
Synthetic Biologics, Inc. (nyse mkt:SYN), a clinical-stage company focused on developing therapeutics to protect the microbiome while targeting pathogen-specific diseases, today announced that it has commenced an underwritten public offering of shares of its common stock. All of the shares in the offering are to be sold by Synthetic Biologics. The Company intends to grant the underwriters a 30-day option to purchase up to an additional 15 percent of the share amount sold to cover over-allotments, if any. The offering is subject to market conditions, and there can be no assurance as to whether or when the offering may be completed, or as to the actual size or terms of the offering.
Jobs in science, technology, engineering and mathematics (STEM) represent some of the best opportunities for workers in today’s economy. The work can be rewarding as well as coming with high pay and good benefits (like a 401(k) and health insurance). Diversity in STEM, however is a problem, one that has captured the attention of CEOs like Jeff Bezos and policymakers including the president himself.
The truism about biopharma being a global industry has never been truer than when it comes to the top 20 IPOs for the first half of this year.
The U.S. had exactly half of the therapeutic, diagnostics, and tools/tech IPOs that were completed or began trading their first shares on public markets during January-June 2015. The rest of the world accounted for the other half, with Europe being home to seven of the 10 ex-U.S. top IPOs, followed by China, Canada, and Bermuda with one each.
I’m a huge fan of R&D collaborations between pharma and academia, so I should be thrilled by Sanofi’s latest tie-up with seven top-tier centers – so why do I have mixed feelings?
On first glance, there’s a lot to like: Sanofi has committed $2.4M per year to seven top centers, including Johns Hopkins, Brigham and Women’s Hospital, and Columbia, to fund about 20-25 seed projects annually, with no strings attached and a wide-open scope. Who knows what will emerge – but it won’t take much for this to look like a pretty good investment for Sanofi.
Funding and Research Opportunities
The following funding opportunity announcements from the NHLBI or other components of the National Institutes of Health, might be of interest:
Notices:
Request for Applications:
Please note that most links to RFAs, PAs, and Guide Notices will take you to the NIH Web site. RFPs will take you to FedBizOpps. Links to RFPs will not work past their proposal receipt date. Archived versions of RFPs posted on FedBizOpps can be found on the FedBizOpps site using the FedBizOpps search function. Under “Document to Search,” select Archived Documents.
The U.S. Department of Health and Human Services' Office of the Assistant Secretary for Preparedness and Response's Biomedical Advanced Research and Development Authority (BARDA) awards a two-year $19.7M contract to Emergent Biosystems (NYSE:EBS) to develop and manufacture cGMP (current good manufacturing practice) lots of three Ebola monoclonal antibodies in CHO (Chinese hamster ovary) cell lines at a scale of 2,000 liters.
American companies continued to attract eye-watering sums of money from venture capitalists in the last quarter, according to a report released Friday.
U.S. firms picked up more than $17 billion in 1,189 deals through the second quarter of 2015, the highest amount since 2000, according to the report by PricewaterhouseCoopers and the National Venture Capital Association, which is based on data from Thomson Reuters.
Last fall, David Narrow and his colleagues reached a critical juncture in the development of their fledgling medical technology company, Sonavex. As Narrow puts it, their brainchild needed nurturing, and a suitable—and affordable—environment for it to happen in.
The company's core concept, he says, was worth the TLC. Narrow and Johns Hopkins Hospital plastic surgeon resident Devin O'Brien Coon, who met while studying in Johns Hopkins' biomedical engineering graduate program in the Whiting School's Center for Bioengineering Innovation and Design, had identified a clinical problem that needed addressing. Each year, more than 550,000 people in the United States undergo medical procedures—soft-tissue reconstruction, organ transplants, bypass surgeries—in which arteries or veins are surgically connected, exposing the patient to the risk of a blood clot. Detecting the clot in a timely manner, before it blocks the vessels and leads to catastrophic complications, becomes paramount. What's needed, Narrow says, is a real-time clot-monitoring device that can be used by nurses post-surgery.
Symptoms associated with Parkinson’s disease include tremor, muscle stiffness, and slowed movement that make it difficult to execute such simple tasks as holding an eating utensil steady, and patients currently have few options for relief outside of a hospital or clinic. Some medications can help, but over time they tend to become less effective. To give Parkinson’s patients another in-home option, a research team of Johns Hopkins University graduate students have invented a headband-shaped device that delivers noninvasive brain stimulation to help suppress symptoms.
The May 15 groundbreaking ceremony for Johns Hopkins Technology Ventures’ new FastForward East location at 1812 Ashland Ave. was about more than just the much-needed additional space the new location will provide the innovation hub.
The ceremony represented the robust growth of the Johns Hopkins innovation culture that is driving economic development in Baltimore, and it signified Baltimore’s strong prospects for becoming a home for tech-savvy companies, offering a wide range of new jobs to Baltimore residents and cultivating a booming, technology-based economy.
Johns Hopkins works not only to foster startups whose products have the potential to improve the well-being of people all over the world, but also to produce savvy investors with business acumen and a strong sense of market dynamics.
Earlier this year, a team of Johns Hopkins University graduate student investors-in-training won the Entrepreneurs’ Choice award at the 2015 mid-Atlantic regional final of the Global Venture Capital Investment Competition (VCIC), during which judges evaluate the competencies of teams of student venture capitalists.
The Francis Crick Institute, the UK’s newest biomedical research facility, and GSK, the UK’s largest pharmaceutical company, are to partner on an open innovation collaboration exploring new avenues of medical research and drug discovery across a broad range of diseases, with a view to achieving breakthroughs in the understanding of human disease.
This is the first collaboration to be established between the Crick and a pharmaceutical company.
Researchers who are developing miniature models of human organs on plastic chips have touted the nascent technology as a way to replace animal models. Although that goal is still far off, it is starting to come into focus as large pharmaceutical companies begin using these in vitro systems in drug development.
“We are pretty excited about the interest we get from pharma,” says Paul Vulto, co-founder of the biotechnology company Mimetas in Leiden, the Netherlands. “It’s much quicker than I’d expected.” His company is currently working with a consortium of three large pharmaceutical companies that are testing drugs on Mimetas’s kidney-on-a-chip. At the Organ-on-a-Chip World Congress in Boston, Massachusetts, last week, Mimetas was one among many drug and biotechnology firms and academic researchers showing off the latest advances in miniature model organs that respond to drugs and diseases in the same way that human organs such as heart and liver do.
Mayo Clinic in Jacksonville, Florida, and United Therapeutics Corporation (NASDAQ: UTHR) today announced a collaboration to build and operate a lung restoration center on the Mayo campus. The goal is to significantly increase the volume of lungs for transplantation by preserving and restoring selected marginal donor lungs, making them viable for transplantation. The restored lungs will be made available to patients at Mayo Clinic and other transplant centers throughout the United States.
Sharath Mekala’s two-person tech startup isn’t a textbook government contractor.
Village Defense, spawned through a startup incubator called 1776, develops a free app that lets neighbors send real-time alerts to one another if they notice suspicious activity. A premium version, which costs $125 a month, is designed for homeowners associations.
William (Brit) Kirwan has been a top university administrator over nearly three decades of vast change in higher education.
During that time he's seen the rise of online learning, a change in the funding dynamic of public colleges, an increased emphasis on obtaining a college education and much, much more. The 77-year-old Kirwan retired last month from his 13-year chancellorship of the University System of Maryland.
Conventional wisdom has long blamed age-related hearing loss almost entirely on the death of sensory hair cells in the inner ear, but research from neuroscientists at Johns Hopkins has provided new information about the workings of nerve cells that suggests otherwise.
In a paper published July 1 in The Journal of Neuroscience, the Johns Hopkins team says its studies in mice have verified an increased number of connections between certain sensory cells and nerve cells in the inner ear of aging mice. Because these connections normally tamp down hearing when an animal is exposed to loud sound, the scientists think these new connections could also be contributing to age-related hearing loss in the mice, and possibly in humans.
We are excited to be returning to Growlers in Gaithersburg this month for BioBuzz MoCo with our Sponsor Maryland Innovation Initiative (MII), a TEDCO program, as we host one of their “Meet TEDCO Program Managers Happy Hour“. The networking event will feature a short presentation followed by happy hour allowing you to network with program managers and your peers. MII is designed to foster the transition of promising technologies with significant commercial potential from the Maryland academic research institutions: Johns Hopkins, Morgan State, and University of Maryland College Park, Baltimore and Baltimore County campuses. The program is designed to promote commercialization of research conducted in the partnership universities and to leverage each institution’s strengths.
The U.S. House of Representatives voted overwhelmingly today in favor of a bipartisan bill that would speed the development of lifesaving drugs and medical devices and provide additional funding for biomedical research.
The bill, called the 21st Century Cures Act, includes provisions that attempt to make the drug approval process less unwieldy and also calls for an additional $8.75 billion in funding for the National Institutes of Health. The bill passed by a 344-77 vote on Friday morning; it now moves to the Senate.
The Johns Hopkins University Applied Physics Laboratory (APL) has provided critical contributions to critical challenges with systems engineering and integration, technology research and development, and analysis. Our scientists, engineers, and analysts serve as trusted advisors and technical experts to the government, ensuring the reliability of complex technologies that safeguard our nation’s security and advance the frontiers of space. We also maintain independent research and development programs that pioneer and explore emerging technologies and concepts to address future national priorities.
GlaxoSmithKline is bringing on board the University of California, San Diego School of Medicine and Moores Cancer Centre to work on a programme aimed at eradicating cancer stem cells to treat leukaemia and other diseases.
The bench-to-bedside project is part of GSK’s Discovery Partnerships with Academia programme, where academic partners become core members of drug-discovery teams to expedite promising basic research into drug discovery and development.
This morning as the House considers H.R. 6, the 21st Century Cures Act, more than 100 patient groups and organizations are voicing their support for the bill’s Innovation Fund to help boost research and support scientists. Chairman Fred Upton (R-MI) has led this effort for a year and a half, keeping patients at the forefront from the beginning. Speaking in support of the bill last night, Upton said, “There is not a single person in this chamber or watching at home today who has not been touched by disease in some way. And it’s time we did something about it.” H.R. 6 is that something. The patient groups listed below voiced their opposition to any attempts to undermine these investments.
Learn about the Target Product Profile (TPP) – a tool used by many biomedical innovators to define, stage, and allocate resources to different aspects of product development work, to frame discussions with stakeholder groups, and to track regulatory interactions and milestones.
Ask questions via the chat window during the live event!