American Gene Technologies (AGT), a leading gene and cell therapy company based in Rockville, MD, selected the Institute of Human Virology (IHV) at the University of Maryland School of Medicine (UMSOM) as a new clinical site for its non-IND study, AGT-CS168, to collect clinical specimens from HIV positive individuals. AGT will use these materials to validate the patient-specific AGT103-T therapeutic manufacturing process. AGT expects AGT103-T will eliminate HIV from the body when infused back into the patient and will decrease or eliminate the need for lifelong antiretroviral treatment.

PHARMACEUTICAL giant GlaxoSmithKline (GSK) unveiled a new, fully automated continuous manufacturing facility and an expanded production building at its Jurong site on Friday, worth a total of S$130 million.

The Maryland Technology Development Corporation (TEDCO), Maryland’s economic engine for technology companies, announced its recent investments through the Maryland Innovation Initiative (MII). With the latest round of funding, MII’s funding count for FY19 includes 26 technology assessment grants and seven start-up investments for a total of $4.22 million. True to its technology agnostic funding history, this year the startups ranged from Cleantech to AI and Biotech.

Researchers at the Johns Hopkins Kimmel Cancer Center, the Greenberg Bladder Cancer Institute, the Bloomberg~Kimmel Institute for Cancer Immunotherapy, the Brady Urological Institute, and the Center for Computational Genomics at Johns Hopkins have received a $3.2 million grant from the National Institutes of Health to study new treatment options for early-stage bladder cancer.

At the close of the 2019 BioHealth Capital Region Forum in April, Floreo Inc. was announced as the winner of the BioHealth Innovation’s 4th annual Crab Trap Competition and the $10,000 grand prize provided by WSGR. Floreo, Inc., which is “…using the power of virtual reality to deliver immersive, fun, and affordable lessons for children and adults with autism spectrum disorder (ASD)…”, was selected by the judges from a group of five finalists.

Access to capital has been an ongoing challenge for biohealth companies in the BioHealth Capital Region (BCHR) and throughout the Mid Atlantic, though recent investment data suggests that capital market access is improving. “PwC/CB Insights ranks the region fourth with $944.07 million in 44 deals and Jones Lang Lasalle tallies $1.1 billion, good enough for third,” stated Rich Bendis, CEO of BioHealth Innovation (BHI), in his keynote speech at the recent The National Cancer Institute (NCI) Technology Transfer Showcase. 

Just one week into 2019, the new year got off to the proverbial roaring start for biopharma mergers and acquisitions (M&A) with the announcement of two multi-billion-dollar deals valued at a total $82 billion—one of them among the top 10 of all time.

Arlington Capital Partners (“Arlington” or the “Firm”), a Washington, D.C. area based private equity investment firm focused on government-regulated sectors, today announced that it has successfully raised its latest fund, Arlington Capital Partners V, L.P. (“Fund V” or the “Fund”) with total capital commitments of approximately $1.7 billion – hitting the Fund’s hard cap. The fundraise, which was significantly oversubscribed, successfully reached its final closing in three months from its launch. The Fund sourced capital commitments from a hand-selected, globally diverse group of marquis investors, including public pension funds, corporate pension funds, insurance companies, fund of funds, and foundations.

The University of Maryland, Baltimore plans an ambitious expansion of its BioPark, with a $200 million building that will nearly double the size of the life science hub to the west of the main medical campus downtown.

Sometimes a Eureka moment sparks a breakthrough in innovation; other times it’s a rush to solve a crisis plaguing society — and the ones you love. That was the case for Martine Rothblatt, CEO of United Therapeutics, a Maryland-based company she founded in 1996, and former CEO of GeoStar and creator of SiriusXM Radio.

The days of Roche having an immunotherapy monopoly on the largest population of small-cell lung cancer patients appear numbered, following the release of data for a competing drug.

If biopharma firms want to get the most out of continuous manufacturing, they must rethink their viral safety strategies. Existing strategies work well for batch-mode production, as hard-won experience attests. These strategies, however, are still being adapted to continuous-mode production, where protocols and equipment preferences are in flux.

By Dr. Kurt Newman, CEO of Children’s National Health System

We have come a long way in pediatric medicine, but not far enough.

For nearly a decade, the chief executives of the nation's children's hospitals and health systems have discussed challenges we face in caring for America's very sickest children, whose life-threatening diseases and congenital conditions put overwhelming burdens on their families.

Novavax, Inc. (NASDAQ: NVAX), a late-stage biotechnology company developing next-generation vaccines for serious infectious diseases, and Catalent Biologics’ Paragon Gene Therapy unit, the leading viral vector development and manufacturing partner for gene therapies, today announced an arrangement under which Paragon Gene Therapy will assume the leases to two Novavax product development and manufacturing facilities, giving it immediate access to state-of-the-art manufacturing equipment, people and space to accelerate the growth of its gene therapy development and manufacturing business.

The University of Maryland School of Pharmacy has launched the nation's first Master of Science program in medical cannabis science and therapeutics.

The university says the degree will provide students with the knowledge and skills needed to support patients and the medical cannabis industry.

As the dominant economic geography of America, metropolitan statistical areas largely determine our success as a nation. These groups of counties with a large central core account for 88.6 percent of jobs, 89.1 percent of wages and 90.0 percent of Gross Domestic Product (GDP). Further, metropolitan statistical areas account for the bulk of innovation such as research and development and patenting activity. Understanding the mechanisms underpinning the growth of top-performing metropolitan areas, and sharing best practices, could assist other communities in boosting their economic fortunes. The Most Dynamic Metropolitan Index, ranking 379 metropolitan areas, seeks to provide an objective measure of the economic vibrancy of communities where the lion’s share of Americans work and live.

Adaptive Biotechnologies has raised the price for its initial public offering, putting itself in a position to raise more cash than any other biotech IPO this year. The Seattle-based company, which makes technology that can read the genetic information of the human immune system, increased its target price to $18 to $19 per share and could raise as much as $327.5 million from investors, according to a new SEC filing.

Health Tech early stage (below $10 million) investing grew consistently from 2010 - 2017, but then stalled in 2018 showing declining deal count in every quarter over the previous year. At the same time, total capital invested was flat. Was it a correction?

Results from Q1 2019 show the segment is back on the growth track. Deal counts won’t yet match 2016 and 2017 levels, but they will be up from 2018 and capital invested in U.S. early stage health tech is likely to be the highest on record.

The company that makes Botox is the subject of the latest biopharma mega-deal.

Chicago-based AbbVie said Tuesday it would acquire Ireland-headquartered Allergan for $63 billion, or $78.45 per share, equal to the former’s Monday closing price. The companies said the deal would provide immediate scale and profitability for AbbVie while allowing the company to diversify into new therapeutic areas like aesthetics.

At the end of November in Washington, D.C., Children's National Health System began work on a historical renovation construction project that will result in a pediatric research and innovation campus with a focus on pediatric medicine.

The Pinkney Innovation Complex for Science and Technology (PIC MC) signed a development agreement today to add a state-of-the-art life sciences office building to the Montgomery College Germantown Campus.

19710 Observation Drive, LLC, a joint venture between Rockville-based, South Duvall and Germantown-based Minkoff Development, will build a $40 million facility on a 5.67-acre parcel at 19710 Observation Drive in Germantown. The 120,000 square foot building will include lab, office, manufacturing and distribution space aimed at companies focused on areas such as biotech, life sciences and cybersecurity.

Investigators at the University of Central Florida (UCF) have just identified the molecular changes that happen when neuronal stem cells are exposed to high levels of an acid commonly found in processed foods. The research team has taken a step closer to showing the link between the food pregnant women consume and the effects on a fetus’ developing brain. Findings from the new study—which described how high levels of propionic acid (PPA), used to increase the shelf life of packaged foods and inhibit mold in commercially processed cheese and bread, reduce the development of neurons in fetal brains—were published recently in Scientific Reports through an article titled “Propionic Acid Induces Gliosis and Neuro-inflammation through Modulation of PTEN/AKT Pathway in Autism Spectrum Disorder.”

Alexandria Real Estate Equities, Inc. ("Alexandria" or the "Company") (NYSE: ARE) announced today the pricing of its upsized public offering of 3,850,000 shares of common stock at a price of $145.00 per share in connection with the forward sale agreements described below. The Company also granted the underwriters a 30-day option to purchase up to 577,500 additional shares. The offering is expected to close on or about June 25, 2019, subject to customary closing conditions.

Women Who Tech, one of the largest nonprofit organizations that funds and showcases women-led ventures, today opened the call for applications for the European-leg of its flagship Women Startup Challenge. Sponsored by Johnson & Johnson Innovation – JLABS, the Office of the Mayor of Paris, and Craig Newmark Philanthropies, 10 early-stage women-led startups with a focus on healthtech will be selected to compete for a $50,000 grant, equity-free, on October 7th at Paris City Hall, Hôtel de Ville.

Immunomic Therapeutics, Inc. (ITI), a privately held, Maryland-based biotechnology company, announced today the promotion of Teri Heiland, Ph.D. to Chief Scientific Officer. In her new role, Dr. Heiland will oversee all of research and development and will play an integral role in business development and the management of ITI’s existing and future partnerships. Dr. Heiland is a co-founder of ITI and has amassed over two decades of executive leadership experience in the biotechnology and life sciences sector. Dr. Heiland’s focus at ITI stems from her background in DNA vaccine design, optimization and development, which has created a broad pipeline of vaccines in oncology, allergy and animal health and has driven licensing deals for ITI with Astellas and Zenoaq. ITI’s investigational UNITE technology platform has the potential to utilize the body’s natural biochemistry to develop a broad immune response and is currently being employed in a Phase II clinical trial as a cancer immunotherapy.

Are you looking to increase the success rate of your state’s SBIR/STTR proposals? If so, a reminder that applications for the Small Business Administration’s Federal and State Technology (FAST) Partnership Program are due next Friday, June 28, at 4 p.m. EDT. This program provides one-year funding to organizations executing programs related to SBIR/STTR outreach, technical assistance, or financial support. As a way to help inform these proposals, SSTI has updated the data from a January Useful Stats article on NIH SBIR/STTR success rates to include the most recent year available, FY 2018.

Jolene Gurevich was going to be an investment banker on Wall Street. But her roots as a competitive Latin ballroom dancer in New York gave her the inspiration to make a move toward entrepreneurship, and Venture for America provided her a clear path into the startup ecosystem in Baltimore. Now manager of the Maryland Technology Enterprise Institute (Mtech Ventures) incubator at the University of Maryland and the Chesapeake Bay Seed Capital Fund, Gurevich guides the trajectory of scientists-turned-entrepreneurs.

Catalent is continuing to expand its fast-growing biologics operations, agreeing to acquire Bristol-Myers Squibb (BMS)’s oral solid, biologics, and sterile product manufacturing and packaging facility in Anagni, Italy, for an undisclosed price.

Johnson & Johnson Innovation is recruiting a Head of Johnson & Johnson Innovation – JLABS @ Washington DC.    The goal of Johnson & Johnson Innovation (JJI) is to advance transformative healthcare solutions that improve the lives of people around the world and, in so doing, to deliver value to Johnson & Johnson (“J&J”).  JJI accomplishes this by catalyzing new science and technology through collaboration and exchange of ideas. This growing team is looking for a colleague inspired to help build and innovate new ways of fostering a productive life-science ecosystem.

This position will be responsible for setting the strategic direction and overseeing all operational activities for JLABS in Washington DC and leading our partnership with Children’s National Health System.  This position will also be part of the Global Johnson & Johnson Innovation - JLABS leadership team. 

Minnowtech, LLC, an aquaculture technology company that provides an imaging platform to enable shrimp farmers to measure shrimp abundance to optimize feeding, announced today it has been awarded a $225,000 Small Business Innovation Research (SBIR) Phase I grant from the National Science Foundation (NSF).

Sanofi will apply Google’s artificial intelligence (AI) and cloud computing capabilities toward developing new drugs, through a collaboration whose value was not disclosed.

The companies said they have agreed to create a virtual Innovation Lab to “radically” transform how future medicines and health services are developed and delivered.

Intrexon has scaled its proprietary yeast fermentation process and is on track to realize production of pure cannabinoids at a target cost of goods of <$1,000/kg. With exclusive global access to Intrexon's technology for microbial production of cannabinoids, Surterra gains a clear research and development roadmap to:

Surterra Wellness

Just 16 months into its existence, a local biotech startup has investors swarming.

Gaithersburg, Md.-based Viela Bio has completed a $75 million Series B funding round, bringing its total raised since launching to more than $350 million.

Attorneys Vern Norviel and Charles Andres recently sat down with Katharine "Kathy" Ku, WSGR’s new chief licensing advisor, to discuss questions and situations that come up in the licensing process. Kathy is an internationally recognized leader in the field of licensing and technology transfer, and spent almost three decades as the executive director of Stanford University’s Office of Technology Licensing. Kathy’s many accomplishments include implementation of the Cohen-Boyer DNA Cloning licensing program which contributed to the creation of the biotechnology industry, and her work on the document: In the Public Interest: Nine Points to Consider in Licensing University Technology. This document, which provides nine principles that continue to influence and guide university licensing, should be read by any start-up contemplating taking a university license.

The National Cancer Institute (NCI) and The Frederick National Laboratory for Cancer Research (FNLCR) recently hosted the third annual Technology Showcase at The FNLCR’s Advanced Technology Research Center (ATRF) in Frederick, Maryland. The event provided industry thought leaders, inventors and entrepreneurs a platform to network, showcase their technologies, and learn more about the tech transfer process, starting a new business and various fundraising strategies.