Governor Martin O’Malley announced today that the State, through the BioMaryland Center, has awarded nearly $1 million to five innovative life sciences companies through its Biotechnology Development Awards program. The companies, which received up to $200,000 each, will use the funding to advance the early detection of Alzheimer’s disease, create a less-invasive treatment for tachycardia patients, enhance animal analgesics, control traumatic bleeds and develop high-quality gluten and allergen-free kosher food products.

“These companies are developing products that are changing the way we feed, fuel and heal our planet and have the potential to impact millions of patients around the world,” said Governor O’Malley. “These awards are critical to ensuring that the life-saving research being done here in Maryland has the opportunity to move to the commercial marketplace.”

UMBC recently earned accolades in three college ranking reports.

The Online College Database recognized the high salaries of UMBC graduates in its list of most affordable colleges.  The website used data from the ”2012-2013 PayScale College Salary Report” to rank UMBC as having the second-highest post-graduation starting salary of colleges in Maryland with annual tuition under $20,000.  According to the report, the average starting salary of a UMBC graduate is $50,300.

Sources inform "Globes" that AstraZeneca plc (NYSE; LSE; OMX: AZN) has teamed with Israeli real estate company Minrav Holdings Ltd. (tase:MNRV) to bid in the Office of the Chief Scientist's biotechnology incubator tender. AstraZeneca will handle the consortium's professional side, and Minrav will be responsible for financing.

The AstraZeneca-Minrav consortium is bidding against a consortium of OrbiMed Israel and the venture capital arms of Johnson & Johnson JNJ and Japan's Takeda Pharmaceuticals Co. Ltd.

The University of Maryland has named Brian Darmody associate vice president for corporate and foundation relations. In this newly-created role, Darmody is charged with leading essential university-wide efforts to develop strategic partnerships between the University of Maryland and the corporate and foundation community.

"Throughout Brian's 30-year career with the university, he has proven to be the perfect candidate to lead this new charge," says UMD Vice President for University Relations Peter Weiler. "His unparalleled ability to develop and nurture mutually beneficial relationships for the university has been integral over the years, and we look forward to the leadership he will bring to this new role."

Taking the helm of EFPIA, Viehbacher says R&D and innovation are the keys to rescuing Europe from its economic slump, but more harmonization across the pharmaceutical sector will be needed too.

Venture capital-backed initial public offerings more than doubled during the second quarter from the previous quarter and rose 90% from a year earlier, with 21 companies raising a combined $2.2 billion during their stock-market debuts, driven by the highest number of biotech venture-backed IPOs in nearly 13 years, according to Thomson Reuters Corp. (TRI, TRI.T) and the National Venture Capital Association.

During the quarter, 13 of the offerings were in the life-sciences sector, representing 62% of the total. Biotech offerings, at 11 deals, marked the highest level since the third quarter of 2000, when 13 companies went public.

The venture capital industry is getting rightsized, with less capital raised and deployed, smaller funds, fewer active venture capital firms, and more regulation. The exit climate has picked up, but is still not at the level required. And valuations are overall more rational, with some exceptions at the later stages or in consumer-facing momentum companies.

However, with the confluence of not one but four big market drivers (discussed below), and the rise of a new technology cycle,  we think this is still a great time to be a venture capitalist or entrepreneur.

The following funding opportunity announcements from the NHLBI or other components of the National Institutes of Health, might be of interest:

NIH Guide Notice:

NOT-EB-13-002: Notice To Extend PAR-10-234 Bioengineering Research Partnerships (BRP) (R01)
The purpose of this notice is to extend PAR-10-234 "Bioengineering Research Partnerships (BRP) (R01)," which supports partnerships for basic, applied, and translational multi-disciplinary research that addresses important biological, clinical or biomedical research problems. The new expiration date is January 8, 2014.

NOT-RM-13-022: Notice of Intent to Publish a Funding Opportunity Announcement for the NIH Health Care Systems Research Collaboratory - Demonstration Projects for Pragmatic Clinical Trials Focusing on Multiple Chronic Conditions (UH2/UH3)
The National Institutes of Health, Office of Strategic Coordination intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications for Demonstration Projects for Pragmatic Clinical Trials focusing on the management of multiple chronic conditions, to be conducted as part of the NIH Health Care Systems Research Collaboratory.

Requests for Applications (RFAs):

RFA-CA-13-008: Person-Centered Outcomes Research Resource (U2C)
The purpose of this Funding Opportunity Announcement (FOA) is to support the creation of a research resource infrastructure for the administration of research investigations using person-centered health outcomes, further referred to as the Person-Centered Outcomes Research Resource (PCORR).

RFA-OD-13-010: Tobacco Control Regulatory Research (R21)
The purpose of this FOA is to encourage biomedical, behavioral, and social science research that will inform the development and evaluation of regulations on tobacco product manufacturing, distribution, and marketing.

RFA-OD-13-011: Tobacco Control Regulatory Research (R01)
The purpose of this FOA is to encourage biomedical, behavioral, and social science research that will inform the development and evaluation of regulations on tobacco product manufacturing, distribution, and marketing.

RFA-OD-13-012: Tobacco Control Regulatory Research (R03)
The purpose of this FOA is to encourage biomedical, behavioral, and social science research that will inform the development and evaluation of regulations on tobacco product manufacturing, distribution, and marketing.

Governor Martin O’Malley announced today that the State, through the BioMaryland Center, has awarded nearly $1 million to five innovative life sciences companies through its Biotechnology Development Awards program. The companies, which received up to $200,000 each, will use the funding to advance the early detection of Alzheimer’s disease, create a less-invasive treatment for tachycardia patients, enhance animal analgesics, control traumatic bleeds and develop high-quality gluten and allergen-free kosher food products.

“These companies are developing products that are changing the way we feed, fuel and heal our planet and have the potential to impact millions of patients around the world,” said Governor O’Malley. “These awards are critical to ensuring that the life-saving research being done here in Maryland has the opportunity to move to the commercial marketplace.”

Integrated BioTherapeutics (IBT) and Stanford University have been jointly awarded a $300,000 Small Business Technology Transfer (STTR) grant from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health. The goal of the grant is to develop a highly effective immunotherapeutic to prevent Hepatitis C Virus (HCV) reinfection in liver transplant patients based on antibodies that limit the ability of the virus to escape treatment via mutations.

Up to 170 million people worldwide are chronically infected with HCV, putting infected individuals at significant risk for cirrhosis, liver failure, and liver cancer. Chronic infection is poorly controlled by current antiviral treatments though there is new optimism with two recent FDA-approved direct acting antivirals, telaprevir and boceprevir. These drugs, however, are not recommended in the transplant setting due to likely adverse drug-drug interactions.

Baltimore City’s Emerging Technology Centers (ETC) is pleased to announce that two of its client companies were recently honored at the 13th Annual 2013 Maryland Incubator Company of the Year (ICOY) Awards. Curiosityville was chosen “Best Education Technology Company” and ADASHI was chosen “Best New Incubator Company” by the judging panel of venture capitalists, government officials and business leaders.

“The Curiosityville team is thrilled to have been selected for this award,” said Susan Magsamen, CEO of Curiosityville. “Part of the credit must go to our affiliation with the ETC their assistance has helped allow us to focus on building the business.”

“Research for research’s sake” is not a refrain you’ll hear from Johns Hopkins Whiting School of Engineering Dean Nicholas Jones.

Universities have been working on increasing the amount of their research being used for commercially available products and services, but in Maryland the process has been somewhat slow. While Hopkins is the most highly funded university by the National Institutes of Health, it lags behind its peers in terms of patents, new companies and other measures of commercialization.

Health and Human Services (HHS) Deputy Secretary Bill Corr announced today that the Department is seeking innovators and entrepreneurs to apply for the HHSentrepreneurs Program.  Launched last year, HHSentrepreneurs connects private sector innovators and entrepreneurs with teams of federal employees working on projects that address some of the biggest challenges in health, health care and human services.

The first individuals hired last October through HHSentrepreneurs are working on critical projects including the Affordable Care Act, health resilience technology, and the nation’s organ transplant system.

“By bringing the best in the public and private sectors together, HHSentrepreneurs is creating an environment in HHS that fosters innovative solutions to new and old challenges,” Deputy Secretary Corr said.

This Funding Opportunity Announcement (FOA) invites Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to implement investigator-initiated clinical trials related to the research mission of the NIAID. This program will utilize the cooperative agreement mechanism (U44) to enable support for hypothesis-driven, milestone-driven clinical trials. Although clinical trials not considered high-risk may be proposed, this program encourages high-risk clinical studies. High-risk does not imply human subject or patient risk, but rather defines a study that contains one or more of the following unique features: involves non-routine interventions, administration of an unlicensed product, or administration of a licensed product for an unapproved indication. Mechanistic studies are also encouraged and can be proposed under this program. However, not more than one clinical trial should be proposed within each grant application. The NIAID has a robust infrastructure for conducting clinical studies that includes independently managed resources provided through grants and contracts, as well as resources that are integrated within existing NIAID-supported clinical trial networks. Proposed clinical trials may use NIAIDs independent infrastructure for clinical studies, however, support will not be provided for studies that propose to use dedicated resources that are part of a NIAID-supported clinical trial network. A Commercialization Plan must be included that details plans for promoting further commercialization of the intervention/product/technology to be derived from or associated with the proposed clinical trial, including plans for promoting and establishing partnerships between the SBIR Phase II awardee and third-party investors and/or strategic partners.

A commercialization program to match up provider, payer and pharma technology needs with willing and able healthcare startups has announced its 10 finalists. Each will receive $100,000 tied to meeting certain performance milestones. They have three to six months to work with the healthcare group they’re matched with, depending on the complexity of the program.

PILOT Health Tech NYC, developed by the New York City Economic Development Corporation and Health 2.0, is holding its demo day today at Blueprint Health’s NYC digs. The program is also supported by StartUp Health.

A new report on sea level rise recommends that the State of Maryland should plan for a rise in sea level of as much as 2 feet by 2050. Led by the University of Maryland Center for Environmental Science, the report was prepared by a panel of scientific experts in response to Governor Martin O'Malley's Executive Order on Climate Change and "Coast Smart" Construction. The projections are based on an assessment of the latest climate change science and federal guidelines.

"The State of Maryland is committed to taking the necessary actions to adapt to the rising sea and guard against the impacts of extreme storms," said Governor Martin O'Malley. "In doing so, we must stay abreast of the latest climate science to ensure that we have a sound understanding of our vulnerability and are making informed decisions about how best to protect our land, infrastructure, and most importantly, the citizens of Maryland."

Startup Maryland (www.startupmd.org), an initiative of the UpGlobal consortium (www.up.co), today announced that UNDER ARMOUR® Founder and CEO Kevin Plank will participate as the first instructor for Raise Your Game™.   

Raise Your Game is Startup Maryland’s bootcamp initiative developed to provide the entrepreneurial community with a structured educational program and to help startup CEOs and founders understand and employ the building blocks of strong startups and startup communities.  The new twist for this bootcamp is that the sessions will be proctored/taught by experienced (often serial) entrepreneurs who are very well-recognized and respected.

The INNo program trains research scientists in the entrepreneurial skills needed to bring technology inventions and services to the healthcare market.

Participants in the INNo program learn to:

• Identify and evaluate the commercial potential of intellectual property
• Understand the business fundamentals related to technology start-ups
• Create a value proposition and business concept for a new product, platform, or service
• Articulate investment opportunities persuasively to potential investors and partners
• Develop a network of resources in the Maryland entrepreneurial community

Ernst & Young unveiled its Entrepreneur of the Year Maryland winners on Wednesday night to a packed ballroom at the Marriott Waterfront Hotel in Baltimore, with honors going to former Advertising.com CEO Scott Ferber, the entire Kelly clan and longtime Living Classrooms head James Piper Bond.

A total of 10 awards were given out during a black-tie affair. The awards program recognizes high-growth entrepreneurs who demonstrate excellence and success in such areas as innovation, financial performance and personal commitment to their businesses and communities. The finalists and winners were selected by a panel of independent judges.

Gaithersburg's largest private employer will add some 110 new jobs to its local and Frederick offices and seeks to take its revenues to unprecedented heights by 2020, a  official told the Gaithersburg mayor and City Council Monday.

MedImmune's Gaithersburg headquarters currently house 2,300 employees, approximately 66 percent of the company's international jobs, MedImmune Executive Vice President of Operations Andy Skibo said, including the addition of 830 jobs over the past five years.

"Virtually all of MedImmune is practically here in Gaithersburg or just up the road in Frederick," Skibo said, but the biotech company continues to expand.

MyBodyCount® (MBC), a health and wellness platform that enables individuals to track their lifestyle-based health risk, today introduced the first-ever clinical health score available to the public. The MBC Health Score was developed using actuarial science working in conjunction with Dr. Hunter Young, Assistant Professor of Medicine and Epidemiology at The Johns Hopkins University School of Medicine (JHUSOM) and Dr. Dhananjay Vaidya, Associate Professor of Medicine at JHUSOM.

The score is based on a panel of biomarkers, referred to as the BodyCount8™, that are predictors of the risk of health events and conditions related to heart, kidney and lung diseases and diabetes. The biomarkers can be affected by modifying behaviors including: eating, exercising, smoking and medication adherence. The score enables consumers to understand their lifestyle-based risk relative to their age group and gender.

Research universities and start-up companies receive funds to further develop technologies in the fields of therapeutic, software, medical, mobile and online technologies

The Maryland Innovation Initiative (MII), which accelerates commercialization and technology transfer from university labs to start-up companies, announced it has awarded $2,960,466 to 29 research projects. Funds were awarded to nine start-up companies and 20 university projects – three of these projects include a partnership between two universities working together on technology development. Awards were given across a variety of industries, including therapeutic, software, medical, mobile and online technologies. MII is administered by the Maryland Technology Development Corporation (TEDCO).

“Maryland has some of the best research universities in the nation and an incredible entrepreneurial spirit, which is evident in the awards granted through the Maryland Innovation Initiative,” said Dominick Murray, Secretary of the Maryland Department of Business and Economic Development. “With a progressive approach to university research and technology development, Maryland is well positioned to build on our history of discovery, innovation and invention.”

Connecticut Innovations is taking a new investment approach as it prepares to launch a $200 million fund to spur bioscience research and development in the state.

The fund, originally pitched by Gov. Dannel P. Malloy and approved by lawmakers during the recent legislative session, will provide grants, equity investments, loans and loan guarantees to bioscience related initiatives over the next 10 years.

In one of his recent blogs at Life Sci VC, Atlas Venture’s Bruce Booth makes the optimists’ case for venture capital investments in the life sciences. Booth’s message is that life sciences venture capital is healthy but misunderstood, but he misses the forest for the trees in important ways.

Based on my 27 years in the venture industry, I would argue that another ten years like the last decade would put life sciences venture capital in serious jeopardy. I’ve seen estimates from the National Venture Capital Association (NVCA) that predict the number of U.S. venture firms will be one-third of the pre-2007 level by the time the post-meltdown shakeout has run its course—and the number of VC partners will be a quarter of what it was. My guess is that life sciences as a subset will fare even worse.

Johns Hopkins University is seeing strong interest for the university’s first business accelerator — a faster than expected response from what director John Fini had projected.

“It’s like we’re tapping into something,” said Fini, who also leads the Office of Intellectual Property and Technology Commercialization on the university’s Homewood campus. “The palate was there. They just didn’t have an outlet.”

The accelerator, called FastForward, opened in January to Hopkins faculty members and students interested in pursuing business ideas with their research. The university is holding an official grand opening for the accelerator June 27.

Following is a list of 10 alliances announced in recent years, mostly by pharma and biotech giants with venture capital funds, ranked by total size of fund in which the biopharma(s) invested. Alliances are listed by their partners; their purpose; the role of their partners; the financial contributions of their partners, where disclosed; rights and/or options on drugs resulting from alliance activity, again where disclosed; and the date the alliance was announced. An additional two alliances did not disclose size of total investment, and therefore are included in the list without a ranking.

Significantly, five of the 12 listed alliances were formed during 2013, and another five last year, reflecting the industry’s increasing view that the alliances will offer a more efficient way of developing new drugs by requiring much less than the billions long spent up-front by biopharmas on internal R&D. While the alliances require much less capital from industry, it remains to be seen whether R&D activity will increase, and more new drugs win approval and reach the market, to justify the reduced investment.

BECTON, Dickinson and Co.’s announcement that it was about to roll out a new, easy-to-use, disposable pen injector called Vystra hardly caused a stir in October.

Although an executive for the Franklin Lakes, New Jersey-based medical technology maker said the injector, unveiled at a Las Vegas convention, would introduce “a new level of flexibility for drug manufacturers,” the announcement made few ripples outside the industry.

Boston Children’s Hospital stirred up some buzz this week when it said its researchers had made a breakthrough that could change the face of diabetes treatment.

On its Vector blog, the hospital called attention to a study published earlier this year in the journal Diabetes that identified a certain pathway in the body as the cause of type 1 diabetes. A team led by Dr. Paolo Fiorina from the hospital’s nephrology department studied hundreds of pathways in animals with diabetes and isolated one, ATP/P2X7R, as a trigger of T-cell attacks on the pancreas that inhibit its ability to produce insulin.

Silicon Valley has long been the epicenter of venture capital-financed high-technology, but a new report shows D.C. is climbing the ranks of best metropolitan areas for venture capital, according to The Atlantic Cities.

Martin Prosperity Institute’s figures for venture capital in 2012 show than the San Francisco-Oakland area has in fact overtaken it as the nation's leading center for venture capital, with investments reaching more than $6.8 million.

Baltimore health IT firm WellDoc expects a new diabetes management tool to help the company double its annual revenue and add thousands of clients over the next few years.

WellDoc recently launched BlueStar, a new smartphone app which helps patients better self-manage diabetes and requires a prescription from a doctor. Ford Motor Co. and Rite Aid Corp. are among the companies that will be offering the tool as a pharmacy benefit to employees.

Last fall, the Federal Laboratory Consortium for Technology Transfer introduced an improved Available Technologies search tool that made it faster and easier to search for federal laboratory inventions available transfer to business partners. This tool reduces the time, effort and guesswork in finding opportunities that meet industry’s needs. Instead of sifting through agency or lab records, users can now do single keyword searches for available technologies. Since the search is based on Google search technologies, users can utilize standard Boolean search engine language to perform their searches. Searches return a powerful set of data, including:

• description of the invention
• application and benefits
• current development and patent status
• name of inventor
• federal laboratory contact person who will facilitate the technology transfer opportunity.

This is the season of inaugurations and internships, with the class of 2014 college grads starting a new chapter in life in a recovering yet still challenging job market, and with students beginning a summer of exploring what to do beyond school lives. Whether it’s a full-time job or an internship, the experience is as much about learning the knowledge and skills as it is about self discovery.

I recently met a white, middle-aged American, who is highly fluent in Mandarin and successful running a center whose work requires fluency in East Asian cultures and languages. With an impressive list of life experiences under his belt, he was obviously happy with his life and career. When asked how he got to this point in life, he insisted it was pure “dumb luck” because he couldn’t have foreseen the many opportunities related to his interests when he was a young man. I can relate to that. I am more confident and content with my work life than ever before, having finally found my ways of relating and contributing to the world around me. I wish I could say this was all by design, when in fact for the first decade in this country my life was defined by heartbreaks and headaches. As a liberal arts major and a generalist with broad interests, I was not as readily employable as those with technical such as IT and engineering, so I struggled for a long time to find my footing.

Johns Hopkins student-built devices—a blood clot detection system and a concealable, hands-free breast pump—have won two of the top three awards in a national contest that recognizes innovative biomedical engineering designs that have high commercial potential and social impact.

The honors were announced June 19 in Philadelphia by the National Collegiate Inventors and Innovators Alliance (NCIIA), as it concluded its annual Biomedical Engineering Innovations, Design, and Entrepreneurship Awards (BMEidea) competition. Johns Hopkins student teams previously earned first-place in this competition in 2012, 2010 and 2007.

The emerging tech town of St. Louis has also become fertile ground for a community of life sciences companies that are ready to bloom — if they can find early stage funding.

“We’ve got a lot of engineers here who have been working for companies like Sigma-Aldrich and Monsanto that have decided to spin off, so we have some great entrepreneurial ventures in the life sciences,” said Kasey Joyce, the director of investor relations for Cultivation Capital.