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Nvidia's Cambridge-1 is expected to come online before the end of the year as the most powerful supercomputer in the U.K. and the 29th fastest in the world. GlaxoSmithKline and AstraZeneca are slated as the first to receive access. (Nvidia)

Nvidia to build the U.K.’s fastest supercomputer for AI drug-hunters at GSK, AstraZeneca and more | Fierce Biotech

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Nvidia's Cambridge-1 is expected to come online before the end of the year as the most powerful supercomputer in the U.K. and the 29th fastest in the world. GlaxoSmithKline and AstraZeneca are slated as the first to receive access. (Nvidia)Through a new partnership with GlaxoSmithKline, AstraZeneca and the U.K.’s National Health Service, the chip maker Nvidia plans to build Great Britain’s most powerful supercomputer—and dedicate its use to artificial intelligence research in healthcare.

Dubbed Cambridge-1, the machine is designed to deliver 400 petaflops of performance, or 400 quadrillion floating-point calculations per second.

When presented with dense systems of linear equations used in AI—such as simulations of molecular models and chemical interactions among potential drug compounds—it is expected to provide 8 petaflops of supercomputing power, ranking it number 29 on the list of the world’s fastest.

Image: Nvidia’s Cambridge-1 is expected to come online before the end of the year as the most powerful supercomputer in the U.K. and the 29th fastest in the world. GlaxoSmithKline and AstraZeneca are slated as the first to receive access. (Nvidia)

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5 trends VCs, investors and founders are talking about right now | Silicon Valley Bank

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Business Trends Icons by Jumsoft on Envato ElementsStartup founders and investors are looking at what could be a murky investment outlook over the next few months or quarters. Slowing markets, rising interest rates and turmoil abroad has caused fluctuation in the markets. While the tech sector may continue providing growth opportunity long term, the near term may also be volatile enough that many founders and investors might be forced to take a different path than originally planned.

 

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UNH Research Finds Angel Investor Behavior Can Be Influenced by Ego | UNH Today

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Media relations logo 9 92 16DURHAM, N.H.—Angel investors—wealthy individuals who provide essential funds for start-ups—often invest under conditions of extreme uncertainty. While their funds can be vital to early-stage ventures, researchers at the University of New Hampshire found that angels’ egos can play a significant role in their investment decisions—the bigger the ego, the larger and more diverse the deal and the lower the number of co-investors.

 

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VIPC’s Virginia Venture Partners Invests in Jeeva to Help Increase Patient Diversity in Clinical Trials – EIN Presswire

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Investing money into stock market investing comput 2022 08 01 04 22 50 utcRICHMOND, VIRGINIA, UNITED STATES, August 31, 2022 /EINPresswire.com/ — Virginia Venture Partners, the equity investment program of Virginia Innovation Partnership Corporation (VIPC), today announced an investment in Manassas, Va.-based Jeeva. Jeeva provides a scalable eClinical Software as a Service (SaaS) platform that helps sponsors and contract research organizations (CROs) accelerate flexible clinical operations while minimizing burden on site staff and patients. Jeeva will use this investment towards commercialization of the SaaS platform to accelerate therapy development for therapeutic areas such as rare diseases, immunology, and oncology in the U.S. and in emerging markets such as Latin America and India, where the company has recently established strategic partnerships.

 

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The fate of the SBIR program hangs in the balance of the next month | Federal News Network

By News Archive

FD1500 150x150In about 30 days, one of the longest running and most successful small business programs will expire.

The House will have 14 days in September with votes scheduled to reauthorize the Small Business Innovation Research (SBIR) program when it returns to Washington, D.C. after Labor Day. Meanwhile, the Senate reconvenes on Sept. 6 and doesn’t spell out how many days it plans to be in D.C. and voting on bills.

To be sure, the fate of the SBIR program hangs in the balance of what Congress can do by Sept. 30.

 

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Sanofi offloads smallpox vaccine business to Emergent BioSolutions in $125M deal | Fierce Pharma

By News Archive

Emergent LogoEmergent BioSolutions is set to add the only FDA-approved smallpox vaccine to its portfolio through a $125 million deal with vaccine giant Sanofi Pasteur.

The agreement means Emergent will inherit an existing CDC contract to build the national stockpile. That 10-year, $425 million contract has around $160 million left to be fulfilled before it ends in 2018. Emergent expects to negotiate a multiyear renewal as part of its involvement in the U.S. government’s counter-bioterrorism effort.

 

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523rd Edition, August 30, 2022

By BHI Weekly Newsletter Archives





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August 30, 2022

FOUNDING MEMBER OF

5th Annual BioHealth Capital Region - Investment Conference

 

BioBuzz: BioHealth Capital Region Forum 2022 Preview

The past few years in the biotech industry have been filled with challenges and promise.

From the rapid and successful deployment of the COVID-19 vaccine and the explosion of the cell and gene therapy sector to a hiring boom, remarkable advances in tissue engineering and strong biomanufacturing growth, the BioHealth Capital Region (BHCR) has played a pivotal role in it all.

To say a lot has changed is the understatement of the century. The question remains, however: Where is the BHCR headed?

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Where are they now? An Update on Former BHI Interns

Since BHI's founding in 2011, the organization has had many interns come through the doors in support of Analytics, Marketing, Communications, Social Media, Business, Legal, Accounting, and more.

BHI wanted to give an update on some names you may remember if you worked with us over the years.

Click here to download the PDF.

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BHI Seeks Senior Life Sciences Business Strategist

Currently reporting to the Vice President of Economic Development, the Senior Life Sciences BusinessStrategist evaluates the commercial potential of emerging technologies and provides recommendations ongo-to-market strategies.

This is a customer facing role with a focus on supporting clients in the development of commercial analysesand federal grant proposals.

The Senior Life Sciences Business Strategist also supervises junior Life Sciences Business Strategists andmanages consultants, as needed.

Click here for more information.

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5th Annual BioHealth Capital Region - Investment Conference

5th Annual BioHealth Capital Region - Investment Conference

Intralytix receives Phase II Fast Track NIH SBIR contract

Intralytix receives Phase II Fast Track NIH SBIR contract to continue development of a universal, scale-independent AI-based platform for manufacturing high titer bacteriophage preparations for clinical applications.

Columbia, Maryland, USA. – August 22, 2022 – Intralytix, Inc. announced today that it has received a Phase II contract in the amount of $1,498,045. This contract is made through the Small Business Innovation Research (SBIR)  program from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH). This project is the continuation of a successfully completed NIAID-funded Phase I contract (see Intralytix, Inc.) and will further leverage Intralytix’s existing proprietary PhageSelector™ program, big data, and manufacturing know-how along with machine learning to advance an artificial intelligence (AI)-based universal manufacturing platform, the PhageEngine™, to deliver methods for producing high titer, high quality bacteriophage preparations suitable for clinical applications. Dr. Alexander Sulakvelidze, President and CEO of Intralytix and the Principal Investigator of the SBIR contract, commented, "We are very pleased to further extend this work with support from NIH after successfully competing Phase I of the project. The resulting technology will significantly increase Intralytix’s capabilities as well as help advance the phage biocontrol and phage therapy fields in general and will ultimately have a very significant positive impact on public health. We look forward to continuing this important project in collaboration with NIH. "

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Tonix Pharmaceuticals develops monkeypox vaccine for future by looking at past

Tonix Pharmaceuticals, a company that has a research lab in Frederick, is developing a vaccine to prepare for a future where the monkeypox virus is endemic outside of Africa.

To do that, the company is looking more than 200 years in the past.

The base infrastructure that Tonix researchers use to design vaccines for infectious diseases is based on a virus called horsepox. That’s the same virus Dr. Edward Jenner used when he started developing the first smallpox vaccine in 1796.

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Johns Hopkins Applied Physics Lab lands Pentagon RDT&E contract worth up to $10.6B

The Johns Hopkins University Applied Physics Laboratory has been awarded a contract for research, development, test and evaluation of military-related technology that could be worth up to $10.6 billion, the Defense Department announced Monday.

The lab, based in Laurel, Maryland, was awarded a $4.4 billion cost-plus-fixed-fee, indefinite-delivery/indefinite-quantity contract for RDT&E programs throughout the DOD that fall “within its core competency areas including strategic systems test and evaluation; submarine security and survivability; space science and engineering; combat systems and guided missiles; air and missile defense and power projection; information technology, simulation, modeling, and operations analysis; and mission related research, development, test and evaluation,” according to the DOD contract award announcement.

Image: Photo of the Johns Hopkins University Applied Physics Lab's Kossiakoff Center. (Photo courtesy of JHU-APL)

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Institute for Bioscience and Biotechnology Research Awarded $6.9M to Design and Test a Vaccine to Combat Hepatitis C

HCV envelope-antibody interaction

The National Institute of Allergy and Infectious Disease (NIAID) awarded a $6.9 million grant to researchers at the Institute for Bioscience and Biotechnology Research (IBBR) to design a vaccine to combat the virus that causes Hepatitis C, an illness that affects an estimated 71 million people worldwide.  Hepatitis C Virus (HCV) puts people at heightened risk for severe liver disease, including fibrosis, cirrhosis, and hepatocellular carcinoma (liver cancer).  Although treatments are available, an HCV vaccine currently does not exist to help prevent infections and reduce the global burden of the disease.

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Governor Hogan Announces Maryland’s State Small Business Credit Initiative Programs Now Open

ANNAPOLIS, MD—Governor Larry Hogan today announced Maryland programs funded by the State Small Business Credit Initiative (SSBCI) are open. Up to $198 million in federal small business relief is being administered by three state agencies: the Maryland Department of Housing and Community Development (DHCD), the Maryland Department of Commerce, and the Maryland Technology Development Corporation (TEDCO). These agencies will use funds to expand and enhance nine existing state business lending and investment programs.

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AstraZeneca Reportedly Seeking Bolt-On Opportunities, could Abandon Vaccines | BioSpace

AstraZeneca CEO Pascal Soriot raised questions Tuesday about the company’s future in vaccines while hinting at potential M&A activity on the near horizon.

In an interview with Reuters, Soriot discussed the company's plans, which he said include building on its portfolio of antibody therapies. AstraZeneca is also considering bolt-on acquisitions in oncology and cardiovascular areas, Soriot said.

Getting out of the COVID-19 Vaccine Business?

Overall, in the COVID-19 space, the company has shifted its resources to antibody therapies.

Image: Pascal Claude Roland Soriot – 23 May 1959 (age 63) France – Wikipedia

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Novel Nanotechnology Supercharges Immune System Molecules to Fight Cancer

Novel Nanotechnology Supercharges Immune System Molecules to Fight Cancer

Researchers from Cytimmune Sciences presented new data at a cancer therapeutics conference in Boston, MA demonstrating the potential of their nanoparticle-based platform to supercharge synergistic immune system stimulators called cytokines.

SUMMARY OF DATA PRESENTED

  • Data focused on industry leading, first-in-class, multi-cytokine immunotherapies
  • CYT-IFNg-TNFa (A dual cytokine immunotherapy nanomedicine)
    • 100x increase in direct cancer cell killing potency vs native cytokines
    • 30x increase in cytokine accumulation in tumor tissue
    • Induction of a cancer specific immune response after treatment
  • Other novel cytokine-based immunotherapies
    • Introduction of nanomedicines including combinations of IL-12, IL-2, IL-15 & IL-1b
    • 175x increase in potency of IL-12 presented on nanoparticles vs. native IL-12
  • CYT-6091 (high dose TNF alpha)
    • Unpublished preclinical data showing CYT-6091 induces cytotoxic T-Cell tumor infiltration
    • Phase 1 clinical safety data and preclinical mechanism of action data

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Deloitte remains largest healthcare consulting firm in United States

Deloitte Consulting remained atop Modern Healthcare’s annual ranking of the largest healthcare management consulting firms based in the US.

Deloitte US’ sizable healthcare consulting practice realized $2.698 billion in revenue in 2021, with $962.8 million coming from healthcare providers.

Guidehouse jumped from third place 2020 to second place in 2021, achieving $970 million in healthcare consulting revenue, with approximately half from providers. The firm was boosted a significant industry acquisition in 2021, adding Dovel, an 1,800-person IT consultancy with a focus on health IT, life sciences, and public safety.

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Forum Preview Article for Newsletter jtk delmarvagroup com Delmarva Group LLC Mail

BioBuzz: BioHealth Capital Region Forum 2022 Preview

By News Archive

Forum Preview Article for Newsletter jtk delmarvagroup com Delmarva Group LLC MailThe past few years in the biotech industry have been filled with challenges and promise.

From the rapid and successful deployment of the COVID-19 vaccine and the explosion of the cell and gene therapy sector to a hiring boom, remarkable advances in tissue engineering and strong biomanufacturing growth, the BioHealth Capital Region (BHCR) has played a pivotal role in it all.

To say a lot has changed is the understatement of the century. The question remains, however: Where is the BHCR headed?

Read More

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