Circulomics Inc has been awarded a Phase I Small Business Innovative Research (SBIR) grant by the National Institutes of Health (NIH) to develop its new Nanobind DNA/RNA extraction technology.
Nanobind is an inexpensive thermoplastic nanomaterial developed for high integrity DNA and RNA extraction. Its hierarchical structure of microscale folds topped by nanoscale wrinkles creates a high binding area silica surface capable of capturing large amounts of high molecular weight (MW) DNA and RNA.
Merck & Co Inc (MRK.N) is considering selling a big portfolio of mature drugs that could fetch more than $15 billion, according to people familiar with the matter, as the U.S. drugmaker continues to streamline businesses to focus on high-growth areas.
Merck, which is also in the process of selling its $14 billion consumer healthcare unit, is working with an investment bank on the potential sale of the off-patent drugs, which could draw interest from generic drugmakers, the people said.
With the decline of great industrial laboratories, such as Bell Labs—home of such major technological advances as the transistor and research that won seven Nobel Prizes, all in physics—many universities are putting increased focus on technological innovation, translational research, and commercialization. Work leading to successful innovations, however, “does not necessarily result in outcomes that are traditionally counted [by universities] in career advancement, such as publication,” write Paul Sanberg, senior vice president for research and innovation at the University of South Florida in Tampa, and his co-authors in an article published 28 April in the Proceedings of the National Academy of Sciences. In fact, it “often requires faculty members with a different working mindset and modus operandi than those conducting purely basic research.”
A team of physicists, psychologists and developers have produced a mobile health platform to make virtual reality and augmented reality more accessible as a self-help tool for treating phobias. Phobius, part of DreamIt Health Baltimore’s inaugural class, has developed a smartphone-enabled tool and is planning a September launch for its consumer product, which includes goggles and an iPhone or Android app.
Phobius comes to Baltimore by way of Barcelona. In addition to the consumer-facing tool, a clinician-facing track is under development. The consumer-facing platform will concentrate on phobias from insects and public speaking to needles. The company plans to market it without any guarantees of its effectiveness in curing these phobias. But it also plans to seek FDA clearance and a CE Mark from European regulators to use the device for treating post traumatic stress disorder and anxiety disorders.
The angel investor market in 2013 continued the upward trend started in 2010 in investment dollars and in the number of investments. Total investments in 2013 were $24.8 billion, an increase of 8.3% over 2012, according to the Center for Venture Research at the University of New Hampshire. A total of 70,730 entrepreneurial ventures received angel funding in 2013, an increase of 5.5% over 2012 investments. The number of active investors in 2013 was 298,800 individuals, an increase of 11.4% from 2012. The increase in both total dollars and the number of investments resulted in a deal size for 2013 that was slightly higher than in 2012 (an increase in deal size of 2.6% from 2012). These data indicate that angels were active investors in 2013 but those that did invest decreased their individual investments from $85,435 in 2012 to $83,050 in 2013, a decrease of 2.8%. The $24.8 billion in total investments is close to the market high of $26.0 billion that occurred in 2007.
In the face of rising drug research and development costs and continued pressures against increasing prices for medicines and health care services, the biopharmaceutical industry must find ways to increase innovation and efficiencies. The Association of University Research Parks (AURP) today announced that leaders from industry and academia will come together at the Janssen Research & Development West Coast Research Center in San Diego on June 23, 2014, for AURP’s BioParks 2014 Meeting . Participants will address recent shifts in pharmaceutical R&D models and the role bioparks play in this evolution.
“Research parks play a vital role in fostering collaboration between universities and the private sector. While this is important across all research-based industries, the need for such collaboration is absolutely critical in the biopharmaceutical space,” said Kevin T. Byrne, MBA, AURP President, and President, The University Financing Foundation.
When I recently sat down with Andrew Skibo, regional VP of supply biologics, global engineering, and real estate at AstraZeneca (AZ), I was the guy with no experience. Sure, I have 20+ years of pharmaceutical industry experience, but after a few minutes of conversation, I learned that this exchange could only be described as one between a veteran and a rookie — and I was the latter.
Skibo has an impressive list of industry accomplishments, including overseeing large-scale capital projects that garnered two International Society for Pharmaceutical Engineering (ISPE) facility of the year awards (FOYA) and two Leadership in Energy & Environmental Design (LEED) Gold awards. But what you can’t conclude from someone’s CV is the skill with which they are able to communicate their wisdom. For instance, I found Skibo to be a patient and skilled communicator, putting me at ease by stating, “If I answer any of these questions in too much detail, stop and fine-tune me as to the level you need.” What follows are his insights on applying a risk-based approach to modeling and planning for biologics manufacturing capacity. Of course, he knows a thing or two about this topic, considering nearly half of AstraZeneca’s 2014 development pipeline falls into the large molecule (biologic) category.
MedStar Health will become the final founding partner of the 1776 tech incubator in Washington, with clinicians and administrators with the Columbia-based health system having a “significant presence” in the incubator to work alongside startups working in the health care arena.
MedStar also plans to offer educational workshops about the evolving health care delivery landscape for entrepreneurs, officials said.
Last year investments in big data dominated health IT deals as 112 deals attracted $712 million in investments, according to a new report by StartUp Health assessing digital health investment trends in 2013 and the start of this year. But in a trend that’s likely to continue this year, sectors that saw the most growth tended to fall into one of two areas. Patient engagement had a 410 percent boost in deal flow, followed by sensors and vital-sign monitoring which showed a 243 percent rise.
Although the number of deals in the first quarter has declined to 133 compared with the same period in 2013, deal size has more than doubled to $1.35 billion compared with $599 million last year.
The NIH Research Evaluation and Commercialization Hub (REACH) program will support proof-of-concept centers (Hubs) that facilitate and accelerate the translation of biomedical innovations into commercial products that improve patient care and enhance health. The REACH Hubs will provide qualified institutions with the initial investment and resources to nurture innovators to develop high priority early-stage technologies within the NIH’s mission by providing: (1) infrastructure for identifying the most promising technologies, (2) funding for product definition studies (e.g. feasibility studies, prototype development, or proof-of-concept studies), (3) coordinated access to expertise in areas required for early stage technology development (including scientific, regulatory, reimbursement, business, legal, and project management), and (4) skills development and hands-on experience in entrepreneurism. Establishing public-private partnerships and providing additional non-federal funds will be critical for success.
