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March 15, 2022

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Dr. Ken Malone, Co-Founder and Managing Director of Early Charm Ventures, Visits BioTalk

Ken Malone, Co-Founder and Managing Director of Early Charm Ventures, Joins BioTalk to discuss his career path, loving Baltimore, and what he sees as next for the BioHealth Capital Region

Listen now via Apple https://apple.co/3MRn94f, Google https://bit.ly/3tTPIpg, Spotify https://spoti.fi/36gfJXw, Amazon https://amzn.to/3MNckQG, and TuneIn https://bit.ly/3i3H3e7.

Ken Malone is a co-founder of Early Charm Ventures, a venture studio founded in 2012 in Baltimore (Charm City) that converts science to business. Early Charm specializes in taking brilliant scientific discoveries made at universities and turning them into companies focused on growth. They don’t chase quick exits. They build companies that create sustainable value.

Click here to view the transcript.

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Open Position: Ventures Analyst and Project Manager at NIH SEED Office

BioHealth Innovation, Inc. (BHI), is a Montgomery County innovation intermediary which translates market-relevant research into commercial success by bringing together management, funding, and markets. BHI is seeking a life science business analyst to support the NIH SEED Office (https://seed.nih.gov/). The analyst will provide business landscape analysis and other project support on product development, corporate strategy, and private investment for NIH-funded companies. This will entail market landscape, technology, and other business intelligence research to support Entrepreneur-in-Residence and other SEED life science commercialization activities.

Download the PDF of the job description.

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Opportunity: Entrepreneur-In-Residence Role with BioHealth Innovation, Inc. and NIH

POSITION DESCRIPTION – Entrepreneur-In-Residence

EIRs will work in collaboration with SEED to mentor innovators and provide guidance to help them de-risk the technical and business elements of their product development projects. EIRs will also help NIH and individual innovators ensure the long-term success of their projects by facilitating connections with investors and strategic partners who can help achieve commercial success and healthcare consumer access. To be successful in this role, entrepreneurial, commercial or product development experience in areas of social impact including wellness & prevention, healthcare access/community health and a wide network in social impact ventures is required.

This position is currently remote (with opportunity for future in-person activities) and part time (20 hrs/week with potential for expansion); occasional travel may be required (when conditions permit).

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Emmes Acquires Casimir, Its Fourth Major Acquisition

Casimir Further Differentiates Emmes' Industry-Leading Rare Disease Research Capabilities

ROCKVILLE, Md., March 10, 2022 /PRNewswire/ -- Emmes, a global, full-service Clinical Research Organization (CRO) dedicated to supporting the advancement of public health and biopharmaceutical innovation, today announced that it has acquired Casimir, a U.S.-based CRO. Casimir has experience in more than 20 rare diseases and has worked with regulators, sponsors and patients to develop outcome measures that capture the nuances of disease progression and treatment benefit.

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Emergent BioSolutions Initiates Phase 1 Study Evaluating Potential Intranasal Treatment for Cyanide Poisoning

GAITHERSBURG, Md., March 11, 2022 (GLOBE NEWSWIRE) -- Emergent BioSolutions Inc. (NYSE: EBS) today announced that it has dosed the first participant in its Phase 1 study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of stabilized isoamyl nitrite (SIAN), a treatment being developed for known or suspected acute cyanide poisoning. Under an existing multi-year contract with the Biomedical Advanced Research and Development Authority (BARDA), and in collaboration with the Southwest Research Institute, Emergent is developing a single-use intranasal spray intended for administration by first responders and medical personnel following a cyanide incident.

“Emergent’s R&D efforts are grounded in our mission – to protect and enhance life,” said Kelly Warfield, Ph.D., senior vice president, research and development at Emergent BioSolutions. “We are committed to advancing unique programs like SIAN, which addresses the need for an easily administered first-line treatment for cyanide poisoning. Intranasal SIAN is being developed for potential use by both civilians and first responders and is part of our portfolio of medical countermeasures focused on priority public health threats identified by the U.S. government.”

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Novavax Announces Launch of Global Vaccine Education Program

-  'We Do Vaccines' and 'Know Our Vax' are new educational efforts that provide information regarding vaccines

-  Programs explain Novavax' commitment to vaccine development and innovation

GAITHERSBURG, Md., March 10, 2022 /PRNewswire/ -- Novavax, Inc. (Nasdaq: NVAX), a biotechnology company dedicated to developing and commercializing next-generation vaccines for serious infectious diseases, today announced the launch of its global unbranded 'We Do Vaccines' and 'Know Our Vax' programs, educational efforts aimed to help protect the health of people everywhere in the fight against COVID-19 and other deadly infectious diseases, such as influenza.

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Gaithersburg's Salubris Biotherapeutics Announces $32 Million Financing to Advance Novel Complex Biologics for Cardiovascular, Oncology, and Neurodegenerative Diseases

– Reports Promising Early Data from Lead Clinical Program, JK07, for the Treatment of Heart Failure with Reduced Ejection Fraction –

– Initiates Enrollment in Second Cohort of JK07 Phase 1 Dose Escalation Study –

(Gaithersburg, MD) – March 7, 2022 – Salubris Biotherapeutics, Inc. (SalubrisBio), a clinical-stage biotechnology company dedicated to discovering and developing novel complex biologic therapeutics, today announced it received $32 million in financing from China-based Shenzhen Salubris Pharmaceuticals Co., Ltd. The investment, which was completed in the fourth quarter of 2021, will be used to advance the current pipeline, including continuation of an ongoing Phase 1b clinical trial and initiation of two additional Phase 1b clinical trials in 2022, and to further expand the pipeline through R&D.

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Johns Hopkins, University of Maryland Medical System to send $4 million in medical supplies to Ukraine

BALTIMORE — The University of Maryland Medical System and Johns Hopkins Medicine have announced they will send more than $4 million worth of medical supplies to support Ukraine, and plan on sending more.

The two major hospital systems are sending items including airway aspirators, medical air compressors, beds, oxygen concentrators, positive pressure ventilators, face masks and shields, respirator kits, gowns, gloves and syringes, according to a press release.

The donation will help clinicians in Ukraine provide emergency medical care in the wake of Russia's invasion.

Mohan Suntha, president and CEO of UMMS, said he plans "to send additional supplies in the future."

Image: Photo by: University of Maryland Medical System Supplies for Ukraine

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Stonebridge Plans 800K SF Of Life Sciences Development In Montgomery County

The Bethesda-based developer is preparing two developments under the moniker "EvolutionLabs" to take advantage of the growing life sciences demand in the county, including a 550K SF development near Pike & Rose, the developer announced Thursday. 

That project, EvolutionLabs at North Bethesda, is planned to include three buildings at the intersection of Old Georgetown and Banneker roads. The first groundbreaking there would be in 2024, according to the release. Stonebridge is under contract to acquire the land for that project, Stonebridge principal Kent Marquis told Bisnow in an email. 

The property will take advantage of the "urban, walkable, transit-oriented," spaces under development near the White Flint Metro station, Marquis said.

Image: Courtesy of Cannon Design Stonebridge and Principal Real Estate's EvolutionLabs concept at 9713 Washingtonian Blvd.

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Small Business Funding | Seed

For a small business with a brilliant new idea in the life sciences, a funding infusion can do wonders to help translate that concept into reality. Did you know that the NIH small business programs are the largest source of early-stage capital for the life sciences in the U.S.? These programs set aside over $1.2 billion non-dilutive funds every year -- specifically to support small business research and development. 

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Incentives and bioscience economic development - Smart Incentives

The Biotechnology Innovation Organization (BIO) and Council of State Bioscience Associations recently released Driving the Bioscience Economy Forward During the COVID-19 Pandemic: Best Practices in State and Regional Bioscience Economic Development Initiatives. The biennial report provides a summary of state programs serving the bioscience industry.

This year’s report devotes substantial attention to incentives. Many of the incentive policies are intended to support the leading trends in state bioscience support (see below). These include incentives to provide funding for companies coming out of university partnerships, industry workforce training and development, and facility development. Others are intended to provide capital to bioscience companies at the early-stage, mid-stage, and manufacturing stage of development, such as angel investor and seed capital tax credits, R&D and innovation investment tax incentives, and tax exemptions, abatements or discounts.   

Image: https://smartincentives.org

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Maryland Inno - Maryland Tech Council takes regional approach with launch of new chapters

The Maryland Tech Council has launched two new regional satellite chapters to directly focus on the burgeoning technology sectors in Greater Baltimore and Prince George's County.

The tech council (MCT) is Maryland's largest technology and life sciences trade association with more than 450 members. The Baltimore and Prince George's regional councils are the first sub-chapters launched by the organization.

Image: Marty Rosendale, CEO of the Maryland Tech Council, said the organization created regional chapters "to intentionally unite and empower stakeholders through local advocacy, outreach and growth." Maryland Tech Council

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Driving the Bioscience Economy Forward During the COVID-19 Pandemic: Best practices in State and Regional Economic Development Initiatives

Indeed, in 2021, the U.S. bioscience industry represents a unique confluence of characteristics essential for addressing these challenges and realizing societal and economic progress: extraordinary innovation that’s saving and improving lives through advancements in biomedical, energy, and advanced food and industrial technologies, along with an expanding mix of employment opportunities with incomes that support a quality standard of living.

The industry is at the forefront of a host of major global challenges related to diagnosing, treating, and curing disease—especially COVID-19 and other infections with pandemic potential. The industry is also ensuring that the world can rely on a safe, affordable, and more sustainable food supply to feed a growing population, as well as developing biobased fuels, chemicals, and other industrial products to help us address climate change.

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Maryland Tech Council Announces 2022 Industry Awards Finalists | citybiz

FREDERICK, Md.–(BUSINESS WIRE)–The Maryland Tech Council is proud to announce the finalists for its annual Industry Awards Celebration. The event honors individuals and companies in the life sciences, technology, and government contracting industries that have made a significant impact in their respective fields. For the first time in two years, the awards ceremony will be held in person, with the winners announced live on May 12th at the Bethesda North Marriott Hotel & Conference Center. Last year over 9,000 people tuned in to the virtual Industry Awards Celebration. Click here to learn more about the event. 

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Bispecific antiviral neutralizing antibodies are twice as nice | Nature Immunology

Human monoclonal antibodies (mAbs) are being used in the clinic to prevent or treat SARS-CoV-2 infection, and experience thus far suggests that combinations of antibodies are potentially able to sustain broad recognition of viral variants as they arise, but developing, testing and approving mAb combination products is complex. One approach to reducing the logistical challenges of combination products is the development of bispecific antibodies (bsAbs) (Fig. 1). In this issue of Nature Immunology, Li et al. report the development and testing of an engineered bispecific human mAb against SARS-CoV-21.

Image: https://www.nature.com

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