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In an unexpected move that could have significant implications for Maryland, Sen. Barbara A. Mikulski will be named the first female chair of the powerful Senate Appropriations Committee on Thursday.

The Baltimore native and Maryland Democrat, who had been the most senior member of the U.S. Senate without a committee gavel, was suddenly in line to head the influential spending panel following behind-the-scenes maneuvering for chairmanships that played out after the death Monday of its former chairman, Sen. Daniel Inouye of Hawaii.

The Democratic caucus is expected to formally approve her chairmanship Thursday.