In some ways Martine Rothblatt, the founder and chairwoman of United Therapeutics, a Maryland-based biotechnology company, and James Park, the CEO and co-founder of consumer fitness company Fitbit, are unusual health care leaders and entrepreneurs. Both came from outside the industry—Rothblatt previously created SiriusXM radio, among other things; meanwhile the inspiration for Park’s popular family of wearable devices was the Nintendo Wii— and neither set out steeped in the regulatory arts of American healthcare.