Research tools developer Canopy Biosciences announced today that it has exclusively licensed a novel gene-editing technology from Washington University in St. Louis and Johns Hopkins University.
The technology, called Tunr, involves targeting translation elongation by introducing consecutive adenosine nucleotides — known as polyA tracks — into a gene coding sequence of interest. As described in Nature Communications earlier this year, inserting polyA tracks into the open reading frame of an mRNA will suppress protein expression by decreasing the efficiency of the translation elongation phase leading to diminished production of protein and mRNA destabilization, thereby diminishing mRNA levels.