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When Marc Andreessen and Ben Horowitz founded their namesake venture firm in 2009, they laid out a clear-but-narrow vision for investing in a new wave of Web-based innovation.

Andreessen, in particular, espoused a net-centric view that was absolute. “No clean tech, no rocket ships, no electric cars. No China or India,” he told Fortune magazine at the time. Biotech likewise was out of the question. In the six years since then, Andreessen Horowitz has grown into a $4 billion VC, and established itself as a leading tech investor. Andreessen’s observation that “software is eating the world” has become an industry axiom, as Web-based services have invaded and taken over financial services, education, and a host of other sectors.