The goal of this workshop is to bring together experts to examine key challenges and proposed recommendations associated with the interface between the circulatory system and the brain. The workshop will cut across the interface and include sessions on upstream blood biomarkers as well as targeted drug delivery, highlighting the potential therapeutic role of exosomes for diagnostic applications as well as targeted drug delivery, and brain sequelae that release biomarkers into the circulation. A common theme that has emerged on both sides of the interface is the role of the immune system and the inflammasome. Sessions will discuss the broad state of the science at the Blood Brain Interface as well as examples of brain injury states (e.g. brain trauma, ischemic stroke, cancer, and neurodegenerative processes) and translational therapeutic developments in this space. The workshop will include experts from across the spectrum of the blood brain interface, not just limited to the blood-brain barrier, to highlight the promise and potential of technologies for diagnostics and therapy development, and encourage potential collaborations across the various groups represented at the meeting as well as generate a set of recommendations that could facilitate development in this promising field.

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